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1. (WO2018078220) INTERLEUKIN 8 (IL-8) AS A PROGNOSTIC AND PREDICTIVE BIOMARKER AND COMPOSITIONS AND VECTORS FOR USE IN ONCOLYTIC IMMUNOTHERAPY

Pub. No.:    WO/2018/078220    International Application No.:    PCT/FI2017/050742
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Sat Oct 28 01:59:59 CEST 2017
IPC: C12N 15/86
C07K 16/24
A61K 35/761
Applicants: TILT BIOTHERAPEUTICS OY
Inventors: TAIPALE, Kristian
HEMMINKI, Akseli
Title: INTERLEUKIN 8 (IL-8) AS A PROGNOSTIC AND PREDICTIVE BIOMARKER AND COMPOSITIONS AND VECTORS FOR USE IN ONCOLYTIC IMMUNOTHERAPY
Abstract:
The present invention relates to an oncolytic viral vector comprising a nucleic acid sequence encoding an anti-interleukin 8 neutralizing antibody.Further, the present invention relates to use of interleukin 8 as a prognostic and predictive biomarkerin oncolytic immunotherapy. In this respect, the present invention is directed to a method ofanalysing whether a subject suffering from a cancer is responsive or non-responsive to the treatment with an oncolytic viral vectorand to a method of monitoringefficacy of an oncolytic immunotherapy.