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1. (WO2018078142) MEANS AND METHODS FOR DETERMINING EFFICACY OF FLUOROURACIL (5-FU) IN COLORECTAL CANCER (CRC) THERAPY

Pub. No.:    WO/2018/078142    International Application No.:    PCT/EP2017/077693
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Sat Oct 28 01:59:59 CEST 2017
IPC: C12Q 1/68
Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
ALACRIS THERANOSTICS GMBH
EXPERIMENTELLE PHARMAKOLOGIE UND ONKOLOGIE (EPO) BERLIN-BUCH GMBH
Inventors: YASPO, Marie-Laure
RISCH, Thomas
JANDRASITS, Christine
LEHRACH, Hans
LANGE, Bodo
SCHÜTTE, Moritz
HOFFMANN, Jens
Title: MEANS AND METHODS FOR DETERMINING EFFICACY OF FLUOROURACIL (5-FU) IN COLORECTAL CANCER (CRC) THERAPY
Abstract:
The present invention relates to a method for determining the susceptibility/responsiveness of (a) cancer cell(s), preferably (a) colorectal cancer cell(s), to the treatment with fluorouracil (5-FU). Further, the present invention relates to a method of selecting (a) cancer cell(s), (a) cancer tissue(s) or (a) tumor sample(s) of colorectal cancer (CRC) with susceptibility to fluorouracil (5-FU). Furthermore, an in vitro method for the identification of a responder for or a subject, preferably a human patient, suffering from colorectal cancer (CRC) to fluorouracil (5-FU) is disclosed. The present invention also relates to a method of monitoring the efficacy of a treatment of the colorectal cancer (CRC) with fluorouracil (5-FU).