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1. (WO2018078053) LIPID NANOPARTICLE MRNA VACCINES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/078053 International Application No.: PCT/EP2017/077517
Publication Date: 03.05.2018 International Filing Date: 26.10.2017
IPC:
A61K 39/12 (2006.01) ,A61K 39/39 (2006.01) ,A61P 31/16 (2006.01) ,A61P 31/14 (2006.01) ,A61K 9/51 (2006.01) ,A61K 31/225 (2006.01) ,A61K 9/16 (2006.01) ,A61K 47/18 (2017.01) ,A61K 9/127 (2006.01) ,C07C 219/06 (2006.01) ,C07C 229/16 (2006.01) ,C07C 233/18 (2006.01) ,C07C 255/24 (2006.01)
Applicants: CUREVAC AG[DE/DE]; Paul-Ehrlich-Straße 15 72076 Tübingen, DE
ACUITAS THERAPEUTICS INC.[CA/CA]; 2714 West 31st Avenue Vancouver, British Columbia V6L 2A1, CA
Inventors: BAUMHOF, Patrick; DE
FOTIN-MLECZEK, Mariola; DE
HEIDENREICH, Regina; DE
HOPE, Michael J.; CA
JASNY, Edith; DE
LAZZARO, Sandra; DE
LIN, Paulo Jia Ching; CA
LUTZ, Johannes; DE
MUI, Barbara; CA
PETSCH, Benjamin; DE
RAUCH, Susanne; DE
SCHMIDT, Kim Ellen; DE
TAM, Ying; CA
Agent: PHARMA CONCEPTS GMBH; Unterer Rheinweg 50 4057 Basel, CH
Priority Data:
PCT/EP2016/07584326.10.2016EP
PCT/EP2016/07592927.10.2016EP
PCT/EP2017/06406609.06.2017EP
Title (EN) LIPID NANOPARTICLE MRNA VACCINES
(FR) VACCINS À ARNM À NANOPARTICULES LIPIDIQUES
Abstract: front page image
(EN) The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.
(FR) L'invention concerne des nanoparticules lipidiques comprenant de l'ARNm, ainsi que leurs utilisations médicales. Les nanoparticules lipidiques selon l'invention comprennent un lipide cationique de formule (I), (II) ou (III) et/ou un lipide PEG de formule (IV), ainsi qu'un composé d'ARNm comprenant une séquence d'ARNm codant pour un peptide ou une protéine antigénique. L'invention concerne également l'utilisation desdites nanoparticules lipidiques en tant que vaccins ou médicaments, en particulier dans la vaccination contre la grippe ou la rage.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)