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1. (WO2018078034) APPARATUS FOR DETERMINING CELLULAR COMPOSITION INFORMATION IN ONE OR MORE TISSUE SAMPLES

Pub. No.:    WO/2018/078034    International Application No.:    PCT/EP2017/077487
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Fri Oct 27 01:59:59 CEST 2017
IPC: G06K 9/00
G02B 21/36
Applicants: KONINKLIJKE PHILIPS N.V.
Inventors: VAREKAMP, Christiaan
WIMBERGER-FRIEDL, Reinhold
HALTER, David
Title: APPARATUS FOR DETERMINING CELLULAR COMPOSITION INFORMATION IN ONE OR MORE TISSUE SAMPLES
Abstract:
The present invention relates to an apparatus (10) for determining cellular composition in one or more tissue sample microscopic images. It is described to provide (210) first image data of at least one tissue sample. The first image data relates to a non-specific staining of a tissue sample of the at least one tissue sample. Second image data of the at least one tissue sample is provided (220). The second image data relates to specific staining of a tissue sample of the at least one tissue sample. Either (i) the tissue sample that has undergone specific staining is the same as the tissue sample that has undergone non-specific staining, or (ii) the tissue sample that has undergone specific staining is different to the tissue sample that has undergone non-specific staining. A non-specific cellular composition cell density map is determined (230) on the basis of the first image data. A specific cellular composition cell density map is determined (240) on the basis of the second image data. Information regarding cellular composition in the at least one tissue sample is determined (250) on the basis of the non-specific cell density map and the specific cell density map.