Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018078010) POLYSUBSTITUTED QUINIC ACID DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/078010 International Application No.: PCT/EP2017/077430
Publication Date: 03.05.2018 International Filing Date: 26.10.2017
IPC:
A61K 31/215 (2006.01) ,C07C 69/757 (2006.01) ,A61P 25/28 (2006.01) ,A61K 31/216 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
69
Esters of carboxylic acids; Esters of carbonic or haloformic acids
74
Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
757
having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
216
of acids having aromatic rings, e.g. benactizyne, clofibrate
Applicants:
PLANT ADVANCED TECHNOLOGIES PAT [FR/FR]; 19 avenue de la Forêt de Haye 54500 VANDOEUVRE-LES-NANCY, FR
Inventors:
BOEGLIN, Damien; FR
WARNAULT, Pierre; FR
Agent:
IPAZ; 16, rue Gaillon 75002 PARIS, FR
Priority Data:
166040326.10.2016FR
Title (EN) POLYSUBSTITUTED QUINIC ACID DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
(FR) DERIVES D'ACIDES QUINIQUES POLYSUBSTITUES ET LEUR UTILISATION POUR LE TRAITEMENT DES MALADIES NEURODÉGÉNERATIVES
Abstract:
(EN) The present invention relates to polysubstituted quinic acid derivatives (abbreviated to "PSQs") of general formula (IA): in which R represents a linear or branched, cyclic or branched cyclic, saturated or unsaturated C2-Cp alkyl group, said group being able to be substituted or unsubstituted, p being a natural integer between 3 and 18, and Q1, Q3, Q4 and Q5 each representing, independently of one another, a hydrogen atom or a group selected from caffeoyl, maloyl, caffeoylmaloyl and maloylcaffeoyl groups, with the proviso that at least one of these radicals is not a hydrogen atom, the stereoisomers thereof and the pharmaceutically or nutraceutically acceptable salts thereof, for the prevention and/or the treatment of a neurodegenerative disease, especially Alzheimer's disease. Another subject of the invention is compounds of formula (IA) per se, a process for preparing such compounds, compounds according to the invention intended to be used as medicament, especially for the prevention and/or treatment of a neurodegenerative disease, in particular Alzheimer's disease, and a pharmaceutical composition comprising at least one compound according to the invention.
(FR) La présente invention concerne des dérivés esters d'acides quiniques poly substitués (abrégé en « QPS »), de formule générale (IA) : dans laquelle R représente un groupe alkyle en C2-CP linéaire ou ramifié, cyclique ou cyclique ramifié, saturé ou insaturé, ledit groupe pouvant être substitué ou non substitué, p étant un entier naturel compris entre 3 et 18, et Q1, Q3, Q4 et Q5 représentent chacun, indépendamment l'un de l'autre, un atome d'hydrogène ou un groupe choisi parmi les groupes caféoyle, maloyle, caféoylmaloyle et maloylcaféoyle, sous réserve qu'au moins un de ces radicaux ne soit pas un atome d'hydrogène, leurs stéréoisomères et leurs sels pharmaceutiquement ou nutraceutiquement acceptables, pour la prévention et/ou le traitement d'une maladie neurodégénérative, notamment la maladie d'Alzheimer. L'invention a également pour objet des composés de formule (IA) en tant que tels; un procédé de préparation de tels composés, des composés selon l'invention destinés à être utilisés comme médicament, notamment pour la prévention et/ou le traitement d'une maladie neurodégénérative, en particulier la maladie d'Alzheimer et une composition pharmaceutique comprenant au moins un composé selon l'invention.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)