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1. (WO2018077926) MONOCLONAL ANTIBODIES BINDING TO THE CD160 TRANSMEMBRANE ISOFORM

Pub. No.:    WO/2018/077926    International Application No.:    PCT/EP2017/077261
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Thu Oct 26 01:59:59 CEST 2017
IPC: C07K 16/28
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
UNIVERSITÉ PARIS DIDEROT - PARIS 7
UNIVERSITÉ DE MONTPELLIER
INSTITUT JEAN GODINOT
INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER
Inventors: BENSUSSAN, Armand
ROBERT, Bruno
MARTINEAU, Pierre
CHENTOUF, Myriam
MARIE-CARDINE, Anne
GUSTINIANI, Jérôme
Title: MONOCLONAL ANTIBODIES BINDING TO THE CD160 TRANSMEMBRANE ISOFORM
Abstract:
The present invention relates to monoclonal antibodies that bind to the CD160-TM isoform. The inventors developed new monoclonal antibodies which bind to the CD160-TM isoform but dot not bind to the CD160 GPI-anchored isoform not to the CD160 soluble isoform.In particular, the antibodies of the present invention are suitable for amplifying NK cell activation and therefore cytotoxic functions NK cells.