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1. (WO2018077847) BARCODED CIRCULAR LIBRARY CONSTRUCTION FOR IDENTIFICATION OF CHIMERIC PRODUCTS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/077847 International Application No.: PCT/EP2017/077111
Publication Date: 03.05.2018 International Filing Date: 24.10.2017
IPC:
C12Q 1/68 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
ROCHE DIAGNOSTICS GMBH [DE/DE]; Sandhofer Straße 116 68305 Mannheim, DE (DE)
ROCHE SEQUENCING SOLUTIONS, INC. [US/US]; 4300 Hacienda Drive Pleasonton, California 94588, US (US)
Inventors:
GUETTOUCHE, Toumy; US
RICHARDSON, Aaron; US
Agent:
HILDEBRANDT, Martin; DE
BURGER, Alexander; DE
GOEHRING, Frank; DE
JENNI, Wolfgang; DE
MISERA, Simon; DE
NASER, Werner; DE
SKOLAUT, Alexander; DE
EISENMANN, Ulrike; DE
MERTES, Maria; DE
HEINEMEYER, Thomas; DE
Priority Data:
62/415,24531.10.2016US
Title (EN) BARCODED CIRCULAR LIBRARY CONSTRUCTION FOR IDENTIFICATION OF CHIMERIC PRODUCTS
(FR) CONSTRUCTION DE BIBLIOTHÈQUE CIRCULAIRE À CODE-BARRES POUR L'IDENTIFICATION DE PRODUITS CHIMÉRIQUES
Abstract:
(EN) The invention is a novel method of constructing libraries for single-molecule sequencing and a composition therefor. The method utilizes barcodes that enable detection and sequencing of chimeric target molecules with great sensitivity. The method finds application in detection gene fusions such as the ones characteristic of cancer.
(FR) L'invention concerne un nouveau procédé de construction de bibliothèques pour le séquençage de molécule unique et une composition correspondante. Le procédé utilise des codes à barres qui permettent la détection et le séquençage de molécules cibles chimériques avec une grande sensibilité. Le procédé trouve une application dans la détection de fusions de gènes telles que celles qui sont caractéristiques du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)