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1. (WO2018077699) BENZYLAMINOPYRIDYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Pub. No.:    WO/2018/077699    International Application No.:    PCT/EP2017/076618
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Thu Oct 19 01:59:59 CEST 2017
IPC: C07D 213/74
C07D 401/12
C07D 405/12
C07D 409/12
C07D 417/12
A61K 31/435
A61P 3/10
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventors: ECKHARDT, Matthias
PETERS, Stefan
WAGNER, Holger
Title: BENZYLAMINOPYRIDYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
Abstract:
The present invention relates to compounds of general formula (I) wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula (I).