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1. (WO2018077242) T CELL RECEPTOR FOR RECOGNIZING SAGE1 ANTIGEN SHORT-CHAIN POLYPEPTIDE

Pub. No.:    WO/2018/077242    International Application No.:    PCT/CN2017/108081
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Sat Oct 28 01:59:59 CEST 2017
IPC: C07K 14/725
C12N 15/12
C12N 15/867
C12N 5/10
A61K 38/17
A61P 35/00
A61P 37/02
Applicants: GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES
中国科学院广州生物医药与健康研究院
Inventors: LI, Yi
李懿
CHEN, An'an
陈安安
Title: T CELL RECEPTOR FOR RECOGNIZING SAGE1 ANTIGEN SHORT-CHAIN POLYPEPTIDE
Abstract:
Provided is are a T cell receptor (TCR) capable of specific binding of short-chain polypeptide VFSTVPPAFI derived from a SAGE1 antigen, a nucleic acid molecule coding the TCR, a vector comprising the nucleic acid molecule, and a cell transducing the TCR. The antigen short-chain polypeptide VFSTVPPAFI can form a complex with HLA A2402 and be transduced together to cell surface.