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1. (WO2018077189) HIGH-AFFINITY SOLUBLE PD-1 MOLECULE

Pub. No.:    WO/2018/077189    International Application No.:    PCT/CN2017/107659
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Thu Oct 26 01:59:59 CEST 2017
IPC: C07K 14/705
C07K 19/00
C12N 15/12
C12N 15/62
A61K 38/17
A61P 35/00
Applicants: GUANGDONG XIANGXUE LIFE SCIENCES, LTD.
广东香雪精准医疗技术有限公司
Inventors: LI, Yi
李懿
LI, Yanyan
李艳艳
Title: HIGH-AFFINITY SOLUBLE PD-1 MOLECULE
Abstract:
Provided is a high-affinity soluble PD-1 molecule. In particular, provided is a programmed death receptor PD-1 molecule wherein the mutation occurs on the basis of the wild-type PD-1 molecule. In addition, the affinity between the PD-1 molecule and the ligand PDL-1 molecule thereof is at least twice the affinity between the wild-type PD-1 molecule and the wild-type PDL-1 molecule. Moreover, the PD-1 molecule in the present invention can effectively improve the killing capability of lymphocytes. Furthermore, also provided are a nucleic acid encoding the PD-1 molecule of the present invention and a complex of the PD-1 molecule of the present invention. The PD-1 molecule of the present invention can be used alone, and can also be used in combination with other molecules.