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|1. (WO2018077189) HIGH-AFFINITY SOLUBLE PD-1 MOLECULE|
|Applicants:||GUANGDONG XIANGXUE LIFE SCIENCES, LTD.
|Title:||HIGH-AFFINITY SOLUBLE PD-1 MOLECULE|
Provided is a high-affinity soluble PD-1 molecule. In particular, provided is a programmed death receptor PD-1 molecule wherein the mutation occurs on the basis of the wild-type PD-1 molecule. In addition, the affinity between the PD-1 molecule and the ligand PDL-1 molecule thereof is at least twice the affinity between the wild-type PD-1 molecule and the wild-type PDL-1 molecule. Moreover, the PD-1 molecule in the present invention can effectively improve the killing capability of lymphocytes. Furthermore, also provided are a nucleic acid encoding the PD-1 molecule of the present invention and a complex of the PD-1 molecule of the present invention. The PD-1 molecule of the present invention can be used alone, and can also be used in combination with other molecules.