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Pub. No.: WO/2018/077183 International Application No.: PCT/CN2017/107634
Publication Date: 03.05.2018 International Filing Date: 25.10.2017
A61L 24/08 (2006.01) ,A61L 24/00 (2006.01)
[IPC code unknown for A61L 24/08][IPC code unknown for A61L 24]
江苏诺瓦立医疗用品有限公司 JIANGSU NEWVALUE MEDICAL PRODUCTS CO., LTD. [CN/CN]; 中国江苏省泰州市 中国医药城口泰东路东侧,新阳路北侧G35幢主楼1-3层,辅楼3层 1-3th Floor of Main Building G35 and 3th Floor of Auxiliary Building Zhongguoyiyaocheng Koutai Road East And Xinyang Road North Taizhou, Jiangsu 225300, CN
上海诺瓦立医疗器械有限公司 SHANGHAI NEWVALUE MEDICAL PRODUCTS CO., LTD. [CN/CN]; 中国上海市 浦东新区张东路1158号2幢501室 Rm 501m, Bldg2 No.1158 Zhangdong Rd Shanghai 201203, CN
周应山 ZHOU, Yingshan; CN
蒋锐 JIANG, Rui; CN
龚祖光 GONG, Zuguang; CN
徐礼勤 XU, Liqin; CN
周适明 ZHOU, Shiming; CN
周晓明 ZHOU, Xiaoming; CN
上海华诚知识产权代理有限公司 WATSON & BAND INTELLECTUAL PROPERTY AGENT LTD.; 中国上海市 长乐路989号世纪商贸广场27楼 27th Fl., the Center, 989 Changle Road Shanghai 200031, CN
Priority Data:
(ZH) 止血粉
(EN) Disclosed is a hemostatic powder which is mainly in the form of a columnar particle, wherein the axial length/diameter of the columnar particle is less than 5; the hemostatic powder comprises a polymer represented by the following structural formula (I), wherein R is selected from at least one of the group consisting of -NH2, -OCH2CH2OH, -OCH2CH2CH2OH, -OH, -ONa, -OK, -OCa; m, n and p represent the number percents of the corresponding repeating units in the polymer molecule, respectively, and satisfy the following relationship: m + n + p = 1, p/(m + n + p) = 0.05 to 0.30; and when the degree of substitution D is defined as = m/(m + n + p), the overall degree of substitution of the columnar particle is defined as Ds, the degree of substitution of the polymer at the center of the cross-section of the columnar particle is defined as Do, and the degree of substitution of the polymer on the edge of the cross-section of the columnar particle is defined as Dx, the following relation is satisfied: Ds = 0.09-0.8, Do/Dx = 0-0.7.
(FR) L'invention concerne une poudre hémostatique qui est principalement sous la forme d'une particule colonnaire, la longueur/diamètre axial de la particule colonnaire étant inférieure à 5; la poudre hémostatique comprend un polymère représenté par la formule structurale (I) suivante, dans laquelle R est choisi parmi au moins l'un du groupe constitué de -NH2, -OCH2CH2OH, -OCH2CH2CH2OH, -OH, -ONa, -OK, -OCa; m, n et p représentent les pourcentages en nombre des unités de répétition correspondantes dans la molécule de polymère, respectivement, et satisfont la relation suivante : m + n + p = 1, p/ (m + n +p) = 0,05 à 0,30; et lorsque le degré de substitution D est défini comme = m/ (m + n +p), le degré global de substitution de la particule colonnaire est défini comme Ds, le degré de substitution du polymère au centre de la section transversale de la particule colonnaire est défini comme Do, et le degré de substitution du polymère sur le bord de la section transversale de la particule colonnaire est défini comme Dx, la relation suivante est satisfaite : Ds = 0,09-0,8, Do/Dx = 0-0,7.
(ZH) 一种止血粉,所述止血粉主要以柱状颗粒的形式存在,所述柱状颗粒的轴长/直径小于5;所述止血粉包含下述结构式(I)所表示的聚合物,其中,所述R是从-NH 2、-OCH 2CH 2OH、-OCH 2CH 2CH 2OH、-OH、-ONa、-OK、-OCa所组成的群中选择的至少1种;m、n和p分别表示聚合物分子中对应重复单元的数量百分比,并满足以下关系式:m+n+p=1,p/(m+n+p)=0.05~0.30;将取代度D定义为=m/(m+n+p),柱状颗粒的总体取代度定义为Ds,柱状颗粒横截面中心点的聚合物的取代度定义为Do,柱状颗粒横截面边缘的聚合物的取代度定义为Dx时,满足以下关系式:Ds=0.09~0.8,Do/Dx=0~0.7。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)