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1. (WO2018076783) CRYSTALLINE FORM II OF DEXTRAL OXIRACETAM, PREPARATION METHOD THEREFOR AND USE THEREOF

Pub. No.:    WO/2018/076783    International Application No.:    PCT/CN2017/092220
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Sat Jul 08 01:59:59 CEST 2017
IPC: A61K 31/4015
A61P 25/08
Applicants: CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED.
重庆润泽医药有限公司
Inventors: YE, Lei
叶雷
Title: CRYSTALLINE FORM II OF DEXTRAL OXIRACETAM, PREPARATION METHOD THEREFOR AND USE THEREOF
Abstract:
The present invention provides a crystalline form of dextral oxiracetam. The crystalline form has a diffraction peak when a diffraction angle, 2θ, is 17.76±0.2°, 20.16±0.2°, 21.20±0.2°, 24.17±0.2°, or 25.88±0.2°. The crystalline form of dextral oxiracetam can promote synthesis of phosphorylcholine and phosphoethanolamine, boosts cerebral metabolism, has a stimulating function on a specific central nervous pathway by means of a blood-brain barrier, and has special biological activity in the field of sedation and the antiepileptic field. The crystalline form of dextral oxiracetam of the present invention is a water-containing crystalline form, contains 0.5 water molecules, loses crystallization water at 73.5±2ºC, and is melted and decomposed at 138.0±2ºC. The crystalline form of dextral oxiracetam of the present invention can stably exist at room temperature and relative humidity of 0-95%, does not transform, is used for storage and formulation processing, and has low requirements for processing or storage humidity.