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1. (WO2018076568) CYCLOARTANE TETRACYCLIC TRITERPENOID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/076568 International Application No.: PCT/CN2017/072816
Publication Date: 03.05.2018 International Filing Date: 03.02.2017
IPC:
A61K 31/56 (2006.01) ,A61P 9/00 (2006.01) ,A61P 9/04 (2006.01) ,A61P 9/06 (2006.01) ,A61P 9/10 (2006.01)
Applicants: HEFEI COSOURCE PHARMACEUTICALS INC.[CN/CN]; No. 358 Ganquan Road, Shushan Hefei, Anhui 230031, CN
HEFEI BLOOMING DRUG SAFETY EVALUATION CO., LTD.[CN/CN]; No. 358 Ganquan Road, Shushan Hefei, Anhui 230031, CN
Inventors: ZHANG, Shanchun; CN
GAO, Shu; CN
LU, Xiaorong; CN
SUN, Hongzhang; CN
BAO, Yijun; CN
YANG, Bin; CN
PENG, Jiashi; CN
Agent: CHINA SCIENCE PATENT & TRADEMARK AGENT LTD.; Suite 4-1105, No. 87, West 3rd Ring North Rd., Haidian District Beijing 100089, CN
Priority Data:
201610936156.X25.10.2016CN
Title (EN) CYCLOARTANE TETRACYCLIC TRITERPENOID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) COMPOSÉ TRITERPÉNOÏDE TÉTRACYCLIQUE DE CYCLOARTANE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 环菠萝烷四环三萜类化合物、其制备方法及其用途
Abstract: front page image
(EN) The present invention relates to the field of natural medicine and pharmaceutical chemistry, and in particular relates to a cycloartane tetracyclic triterpenoid compound (I), a preparation method therefor and the medical use thereof. Pharmacodynamic experiments prove that the compound of the present invention has a pharmacological activity on heart and cerebral vessels and is used to prevent or treat cardiovascular and cerebrovascular diseases such as arrhythmia, myocardial infarction and coronary heart disease.
(FR) La présente invention concerne le domaine de la médecine naturelle et de la chimie pharmaceutique, et concerne en particulier un composé triterpénoïde tétracyclique de cycloartane (I), son procédé de préparation et son utilisation médicale. Des expériences pharmacodynamiques prouvent que le composé de la présente invention a une activité pharmacologique sur les vaisseaux du coeur et du cerveau et est utilisée pour prévenir ou traiter des maladies cardiovasculaires et cérébrovasculaires telles que l'arythmie, l'infarctus du myocarde et la coronaropathie.
(ZH) 本发明涉及天然药物及药物化学领域,具体涉及一类环菠萝烷四环三萜类化合物(I)、其制备方法及其医药用途。药效学试验证明本发明的化合物具有心脑血管药效活性,用于心律失常、心肌梗死、冠心病等心脑血管疾病的预防或治疗。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)