Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018076568) CYCLOARTANE TETRACYCLIC TRITERPENOID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/076568 International Application No.: PCT/CN2017/072816
Publication Date: 03.05.2018 International Filing Date: 03.02.2017
IPC:
A61K 31/56 (2006.01) ,A61P 9/00 (2006.01) ,A61P 9/04 (2006.01) ,A61P 9/06 (2006.01) ,A61P 9/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
04
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
06
Antiarrhythmics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants:
合肥合源药业有限公司 HEFEI COSOURCE PHARMACEUTICALS INC. [CN/CN]; 中国安徽省合肥市 蜀山区甘泉路358号 No. 358 Ganquan Road, Shushan Hefei, Anhui 230031, CN
合肥诺明药物安全研究有限公司 HEFEI BLOOMING DRUG SAFETY EVALUATION CO., LTD. [CN/CN]; 中国安徽省合肥市 蜀山区甘泉路358号 No. 358 Ganquan Road, Shushan Hefei, Anhui 230031, CN
Inventors:
张善春 ZHANG, Shanchun; CN
高署 GAO, Shu; CN
鲁晓蓉 LU, Xiaorong; CN
孙宏张 SUN, Hongzhang; CN
包益军 BAO, Yijun; CN
杨宾 YANG, Bin; CN
彭家仕 PENG, Jiashi; CN
Agent:
中科专利商标代理有限责任公司 CHINA SCIENCE PATENT & TRADEMARK AGENT LTD.; 中国北京市 海淀区西三环北路87号4-1105室 Suite 4-1105, No. 87, West 3rd Ring North Rd., Haidian District Beijing 100089, CN
Priority Data:
201610936156.X25.10.2016CN
Title (EN) CYCLOARTANE TETRACYCLIC TRITERPENOID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) COMPOSÉ TRITERPÉNOÏDE TÉTRACYCLIQUE DE CYCLOARTANE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 环菠萝烷四环三萜类化合物、其制备方法及其用途
Abstract:
(EN) The present invention relates to the field of natural medicine and pharmaceutical chemistry, and in particular relates to a cycloartane tetracyclic triterpenoid compound (I), a preparation method therefor and the medical use thereof. Pharmacodynamic experiments prove that the compound of the present invention has a pharmacological activity on heart and cerebral vessels and is used to prevent or treat cardiovascular and cerebrovascular diseases such as arrhythmia, myocardial infarction and coronary heart disease.
(FR) La présente invention concerne le domaine de la médecine naturelle et de la chimie pharmaceutique, et concerne en particulier un composé triterpénoïde tétracyclique de cycloartane (I), son procédé de préparation et son utilisation médicale. Des expériences pharmacodynamiques prouvent que le composé de la présente invention a une activité pharmacologique sur les vaisseaux du coeur et du cerveau et est utilisée pour prévenir ou traiter des maladies cardiovasculaires et cérébrovasculaires telles que l'arythmie, l'infarctus du myocarde et la coronaropathie.
(ZH) 本发明涉及天然药物及药物化学领域,具体涉及一类环菠萝烷四环三萜类化合物(I)、其制备方法及其医药用途。药效学试验证明本发明的化合物具有心脑血管药效活性,用于心律失常、心肌梗死、冠心病等心脑血管疾病的预防或治疗。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)