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1. (WO2018076228) METHOD FOR EVALUATING RISK OF DRUG HYPERSENSITIVITY REACTION INDUCED BY SULFAMETHOXAZOLE AND/OR TRIMETHOPRIM

Pub. No.:    WO/2018/076228    International Application No.:    PCT/CN2016/103537
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Fri Oct 28 01:59:59 CEST 2016
IPC: C12N 15/11
C12Q 1/68
Applicants: CHANG GUNG MEMORIAL HOSPITAL, LINKOU
长庚医疗财团法人林口长庚纪念医院
Inventors: CHUNG, Wen-Hung
钟文宏
HUNG, Shuen-Iu
洪舜郁
Title: METHOD FOR EVALUATING RISK OF DRUG HYPERSENSITIVITY REACTION INDUCED BY SULFAMETHOXAZOLE AND/OR TRIMETHOPRIM
Abstract:
Provided is a method for evaluating the risk of drug hypersensitivity reaction induced by antibiotics sulfamethoxazole and/or trimethoprim. The drug hypersensitivity reaction comprises: maculopapular eruption, fixed drug eruption, Stevens Johnson Syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms. A specific HLA genotype is associated with the drug hypersensitivity reaction induced by the antibiotics sulfamethoxazole and/or trimethoprim.