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1. (WO2018076107) COMBINATION THERAPY WITH MINOCYCLINE AND HYDROXYCHLOROQUINE FOR THE TREATMENT OF MULTIPLE SCLEROSIS (MS)
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Pub. No.: WO/2018/076107 International Application No.: PCT/CA2017/051268
Publication Date: 03.05.2018 International Filing Date: 24.10.2017
IPC:
A61K 31/65 (2006.01) ,A61K 31/4706 (2006.01) ,A61P 21/00 (2006.01) ,A61P 25/28 (2006.01) ,C07C 225/20 (2006.01) ,C07D 215/46 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
65
Tetracyclines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4706
4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
225
Compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly-bound oxygen atoms not being part of a -CHO group, e.g. amino ketones
20
having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38
Nitrogen atoms
42
attached in position 4
46
with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
Applicants:
UTI LIMITED PARTNERSHIP [CA/CA]; 100 - 3553 31st Street NW Calgary, Alberta T2L 2K7, CA
Inventors:
YONG, Voon Wee; CA
KOCH, Marcus; CA
METZ, Luanne; CA
FAISSNER, Simon; DE
MISHRA, Manoj; CA
Agent:
VICKERS, Mark F.; CA
DAMIANI, Michael; CA
EVENSON, Brandon; CA
FRITZ, Joachim T.; CA
WOOD, David; CA
ALLARD, Louis B.; CA
BEHMANN, Curtis B.; CA
BOOCOCK, Graeme R.; CA
DEKLEINE, Geoffrey; CA
HUNG, Shin; CA
KEELER, Todd; CA
MARSMAN, Kathleen E.; CA
MUELLER-NEUHAUS, Jason R.; CA
NAUMAN, David A.; CA
PUNDSACK, Scott; CA
COGHLAN, Jeffrey; CA
GORDON, Jeff; CA
RAOUL, Jennifer; CA
SILVER, Gail C.; CA
SOJONKY, Andrew D.; CA
WEBB, Timothy; CA
ZIMMERMAN, Gord; CA
Priority Data:
62/412,55525.10.2016US
Title (EN) COMBINATION THERAPY WITH MINOCYCLINE AND HYDROXYCHLOROQUINE FOR THE TREATMENT OF MULTIPLE SCLEROSIS (MS)
(FR) TRAITEMENT D'ASSOCIATION À BASE DE MINOCYCLINE ET D'HYDROXYCHLOROQUINE POUR LE TRAITEMENT DE LA SCLÉROSE EN PLAQUES (SEP)
Abstract:
(EN) In one aspect, there is provided a method of treating, prophylaxis, or amelioration of a neurological disease by administering to a subject in need thereof minocycline, or a functional derivative thereof, and hydroxychloroquine, or a functional derivative thereof. In a specific example, the neurological disease is multiple sclerosis (also referred to as "MS").
(FR) Dans un aspect, l'invention concerne une méthode de traitement, de prophylaxie ou d'amélioration d'une maladie neurologique par l'administration, au patient le nécessitant, de minocycline ou d'un dérivé fonctionnel correspondant, et d'hydroxychloroquine ou d'un dérivé fonctionnel correspondant. Dans un exemple spécifique, la maladie neurologique est la sclérose en plaques (également désignée par l'abréviation "SEP").
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)