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1. (WO2018076060) IMPROVED GENERATION OF MUSCLE LINEAGE CELLS AND THERAPEUTIC USES THEREOF

Pub. No.:    WO/2018/076060    International Application No.:    PCT/AU2017/051177
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Fri Oct 27 01:59:59 CEST 2017
IPC: C12N 5/077
A61K 31/5377
A61P 21/06
Applicants: GENEA BIOCELLS USA (HOLDINGS), INC.
Inventors: SCHMIDT, Uli
DE LA GARZA, Anabel
KISELYOV, Alexander
Title: IMPROVED GENERATION OF MUSCLE LINEAGE CELLS AND THERAPEUTIC USES THEREOF
Abstract:
Methods and compositions for producing mature myotubes are provided herein. In some instances, the method involves contacting a myoblast in an in vitro culture with a compound, wherein the contacting the myoblast in the in vitro culture with the compound results in generation of mature myotubes or myotube-like cells. In some cases, methods of treatment are provided involving treating a subject with a compound such as a Chk1 inhibitor in order to treat muscle deficiency. The compound may be administered as a stand-alone therapy or in combination with a cell therapy, such as introduction of muscle precursor cells such as satellite cells or myoblasts. Methods for identifying compounds that induce formation of mature myotubes or myotube-like cells from myoblasts are also provided herein, as well as methods of using the identified compounds to treat subjects.