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1. WO2018070874 - MEANS AND METHODS FOR REDUCING OR AVOIDING ANTIBIOTIC RESISTANCE AND SPREAD OF VIRULENCE IN HUMAN PATHOGENS

Publication Number WO/2018/070874
Publication Date 19.04.2018
International Application No. PCT/NL2017/050671
International Filing Date 12.10.2017
Chapter 2 Demand Filed 07.08.2018
IPC
A61K 31/05 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
A61K 31/277 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
275Nitriles; Isonitriles
277having a ring, e.g. verapamil
A61K 31/454 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61P 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
CPC
A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
A61K 31/277
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
275Nitriles; Isonitriles
277having a ring, e.g. verapamil
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • RIJKSUNIVERSITEIT GRONINGEN [NL]/[NL]
Inventors
  • DOMENECH, Arnau
  • VEENING, Jan-Willem
Agents
  • JANSEN, CM.
Priority Data
16193558.012.10.2016NL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MEANS AND METHODS FOR REDUCING OR AVOIDING ANTIBIOTIC RESISTANCE AND SPREAD OF VIRULENCE IN HUMAN PATHOGENS
(FR) MOYENS ET PROCÉDÉS POUR RÉDUIRE OU ÉVITER LA RÉSISTANCE AUX ANTIBIOTIQUES ET LA PROPAGATION DE VIRULENCE CHEZ DES PATHOGÈNES HUMAINS
Abstract
(EN)
The invention relates to the field of medicine. In particular, it relates to means and methods for reducing or avoiding the acquisition of antibiotic resistance. Provided is an agent capable of reducing the proton motive force (PMF) in bacteria for use in reducing or preventing the acquisition of antibiotic resistance of a commensal bacterium, like Streptococcus pneumoniae, that resides in the nasopharynx of a mammalian subject, wherein the use is not for the purpose of carrying out therapy on the human or animal body.
(FR)
La présente invention concerne le domaine de la médecine. En particulier, l'invention concerne des moyens et des procédés pour réduire ou éviter l'acquisition de la résistance aux antibiotiques. L'invention concerne un agent permettant de réduire la force proton-motrice (FPM) dans des bactéries pour utilisation dans la réduction ou la prévention de l'acquisition de la résistance aux antibiotiques d'une bactérie commensale, telle que Streptococcus pneumoniae, qui réside dans le rhinopharynx d'un sujet mammifère, l'utilisation n'ayant pas pour but de conduire une thérapie sur le corps humain ou animal.
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