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1. (WO2018068021) INHIBITORS OF GLUCOCORTICOID RECEPTOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/068021    International Application No.:    PCT/US2017/055660
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
IPC:
C07J 17/00 (2006.01), C07J 41/00 (2006.01), C07J 43/00 (2006.01), C07J 51/00 (2006.01)
Applicants: ORIC PHARMACEUTICALS, INC. [US/US]; 240 E. Grand Avenue, 2nd Floor South San Francisco, California 94080 (US)
Inventors: SUN, Daqing; (US).
MCGEE, Lawrence R.; (US).
DU, Xiaohui; (US).
ZHU, Liusheng; (US).
YAN, Xuelei; (US).
REW, Yosup; (US).
EKSTEROWICZ, John; (US).
MEDINA, Julio C.; (US).
FANTIN, Valeria R.; (US).
ZHOU, Haiying; (US).
BALBAS, Minna Delarae; (US)
Agent: SMITH, Deborah M.; (US)
Priority Data:
62/405,801 07.10.2016 US
62/526,331 28.06.2017 US
Title (EN) INHIBITORS OF GLUCOCORTICOID RECEPTOR
(FR) INHIBITEURS DE RÉCEPTEURS GLUCOCORTICOÏDES
Abstract: front page image
(EN)The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
(FR)La présente invention concerne généralement des compositions et des méthodes de traitement du cancer et de l'hypercortisolisme. L'invention concerne des composés dérivés stéroïdiens substitués et des compositions pharmaceutiques comprenant lesdits composés. Les composés et compositions selon l'invention sont utiles pour inhiber les récepteurs glucocorticoïdes. Ces composés et compositions sont en outre utiles pour le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)