WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018068017) HETEROCYCLIC COMPOUNDS AS INHIBITORS OF RAS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/068017    International Application No.:    PCT/US2017/055656
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
IPC:
C07D 401/04 (2006.01), C07D 403/04 (2006.01), C07D 403/14 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), A61K 31/4035 (2006.01), A61K 31/437 (2006.01), A61P 35/00 (2006.01), C07D 513/04 (2006.01)
Applicants: ARAXES PHARMA LLC [US/US]; 3033 Science Park Road, Suite 220 San Diego, California 92121 (US)
Inventors: WU, Tao; (US).
WANG, Yi; (US).
LI, Liansheng; (US).
FENG, Jun; (US).
LIU, Yuan; (US).
REN, Pingda; (US).
LIU, Yi; (US)
Agent: HARWOOD, Eric, A.; (US).
OBEIDAT, Baha, A.; (US).
KUMABE, Blake, K.; (US).
SOLTANI, Bobby, B.; (US).
SARGEANT, Brooke; (US).
QUIST, Brooke, W.; (US).
ROTH, Carol, J.; (US).
EIDT, Chandra, E.; (US).
O'BRIEN, Daniel; (US).
CARLSON, David, V.; (US).
STARK, Duncan; (US).
TARLETON, E., Russell; (US).
SUN, Eileen, S.; (US).
ABRAMONTE, Frank; (US).
HAN, Hai; (US).
TALBERT, Hayley, J.; (US).
CARTER, James, J.; (US).
WHITE, James, A. D.; (US).
BARRETT, Jared, M.; (US).
PEPE, Jeffrey, C.; (US).
DANLEY, Jeffrey, E.; (US).
SAKOI, Jeffrey, M.; (US).
BAUNACH, Jeremiah, J.; (US).
KARLEN, John, R.; (US).
MORGAN, John, A.; (US).
WAKELEY, John, J.; (US).
COE, Justin, E.; (US).
HENCKEL, Karen, M.; (US).
HEFTER, Karl, A.; (US).
HERMANNS, Karl, R.; (US).
MORGAN, Kevan, L.; (US).
COSTANZA, Kevin, S.; (US).
LINFORD, Lorraine; (US).
COOPER, Michael, P.; (US).
RUSYN, Paul; (US).
LIN, Qing; (US).
HALLER, Rachel, A.; (US).
IANNUCCI, Robert; (US).
KOVELMAN, Robert, L.; (US).
WEBB, Samuel, E.; (US).
LEEK, Shoko, I.; (US).
ROSENMAN, Stephen, J.; (US).
ABEDI, Syed; (US).
SATAGAJ, Thomas, J.; (US).
BOLLER, Timothy, L.; (US).
LIGON, Toby, J.; (US).
FERRON, William, O., Jr.; (US)
Priority Data:
62/405,701 07.10.2016 US
62/450,966 26.01.2017 US
Title (EN) HETEROCYCLIC COMPOUNDS AS INHIBITORS OF RAS AND METHODS OF USE THEREOF
(FR) COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE RAS ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein A, B, R", Q, W, X, Y, Z, n1, n2and '--" are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also disclosed.
(FR)La présente invention concerne des composés ayant une activité en tant qu'inhibiteurs de la protéine KRAS mutante G12C. Les composés ont la structure suivante (I) : ou un sel, stéréoisomère ou promédicament pharmaceutiquement acceptable de ceux-ci, dans laquelle A, B, R", Q, W, X, Y, Z, n 1 , n 2 et '--" sont tels que définis dans la description. L’invention concerne en outre des procédés associés à la préparation et à l'utilisation de ces composés, des compositions pharmaceutiques comprenant ces composés et des procédés de modulation de l'activité de la protéine KRAS mutante G12C pour le traitement de troubles tels que le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)