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1. (WO2018068008) T CELLS EXPRESSING MEMBRANE-ANCHORED IL-12 FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/068008    International Application No.:    PCT/US2017/055645
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
IPC:
C07K 14/54 (2006.01)
Applicants: BOARD REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 210 West 7th St. Austin, TX 78701 (US)
Inventors: LI, Shulin; (US).
HU, Jiemiao; (US).
XIA, Xueqing; (US)
Agent: BYRD, Marshall, P.; (US)
Priority Data:
62/405,796 07.10.2016 US
Title (EN) T CELLS EXPRESSING MEMBRANE-ANCHORED IL-12 FOR THE TREATMENT OF CANCER
(FR) LYMPHOCYTES T EXPRIMANT IL-12 ANCRÉE SUR MEMBRANE POUR LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)Provided herein are polypeptides comprising membrane-anchored IL-12. Also provided herein are T cells expressing the membrane-anchored IL-12. Further, methods of treating cancer comprising administering T cells expressing membrane -anchored IL-12 are provided herein. Also provided are combination treatments comprising T cells expressing membrane-anchored IL-12 and T ceil chemoattractant-inducing chemokines. In addition, methods are provided for activating T cells to express NKG2D and methods of their use in the treatment of cancer.
(FR)La présente invention concerne des polypeptides comprenant l'IL-12 ancrée sur membrane. L'invention concerne également des lymphocytes T exprimant IL-12 ancrée sur membrane. En outre, l'invention concerne des méthodes de traitement du cancer consistant à administrer des lymphocytes T exprimant IL-12 ancrée sur membrane. L'invention concerne également des traitements combinés comprenant des lymphocytes T exprimant IL-12 ancrée sur membrane et des chimiokines induisant la chimioattraction des lymphocytes T. L'invention concerne encore en outre des méthodes d'activation de lymphocytes T de sorte à exprimer NKG2D et des méthodes d'utilisation de celles-ci dans le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)