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1. (WO2018067993) COMPOSITIONS AND METHODS FOR T-CELL RECEPTORS REPROGRAMMING USING FUSION PROTEINS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/067993    International Application No.:    PCT/US2017/055628
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
IPC:
C07K 16/28 (2006.01), A61K 39/00 (2006.01)
Applicants: TCR2 THERAPEUTICS INC. [US/US]; 450 Kendall Street Cambridge, Massachusetts 02142 (US)
Inventors: BAEUERLE, Patrick; (US).
SIECZKIEWICZ, Gregory; (US).
HOFMEISTER, Robert; (US)
Agent: MCANDREW, Christopher; (US).
HOSTETLER, Michael J.; (US)
Priority Data:
62/405,551 07.10.2016 US
62/510,108 23.05.2017 US
Title (EN) COMPOSITIONS AND METHODS FOR T-CELL RECEPTORS REPROGRAMMING USING FUSION PROTEINS
(FR) COMPOSITIONS ET MÉTHODES DE REPROGRAMMATION DES RÉCEPTEURS DES LYMPHOCYTES T FAISANT APPEL À DES PROTÉINES DE FUSION
Abstract: front page image
(EN)Provided herein are T-cell receptor (TCR) fusion proteins (TFPs), T-cells engineered to express one or more TFPs, and methods of use thereof for the treatment of diseases, including cancer.
(FR)La présente invention concerne des protéines de fusion (TFP) impliquant le récepteur des lymphocytes T (TCR), des lymphocytes T modifiées pour exprimer une ou plusieurs TFP, ainsi que des méthodes d'utilisation de celles-ci pour le traitement de maladies, notamment du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)