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1. (WO2018067946) METHODS OF TREATING PATIENTS WITH A RETINOIC ACID RECEPTOR-ALPHA AGONIST AND AN ANTI-CD38 ANTIBODY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/067946 International Application No.: PCT/US2017/055562
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
Chapter 2 Demand Filed: 04.05.2018
IPC:
A61K 31/192 (2006.01) ,A61K 31/203 (2006.01) ,A61K 39/395 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
20
having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
203
Retinoic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: SYROS PHARMACEUTICALS, INC.[US/US]; 620 Memorial Drive, Suite 300 Cambridge, MA 02139, US
Inventors: MCKEOWN, Michael, R.; US
COLLINS, Cindy; US
EATON, Matthew, Lucas; US
GUENTHER, Matthew, G.; US
KE, Nan; US
LOPEZ, Jeremy; US
CHEN, Mei, Wei; US
ORLANDO, David, A.; US
AUSTGEN, Kathryn; US
FIORE, Christopher; US
LEE, Emily, Payton; US
FRITZ, Christian, C.; US
Agent: MCCARTY, Catherine, M.; US
ARGENTIERI, Steven, R.; US
ASHRAF, Shovon; US
BRODOWSKI, Michael; US
BUCHMAN, Joshua, J.; US
Priority Data:
62/405,16406.10.2016US
62/449,45023.01.2017US
62/564,69028.09.2017US
Title (EN) METHODS OF TREATING PATIENTS WITH A RETINOIC ACID RECEPTOR-ALPHA AGONIST AND AN ANTI-CD38 ANTIBODY
(FR) MÉTHODES DE TRAITEMENT DE PATIENTS À L'AIDE D'UN AGONISTE DU RÉCEPTEUR ALPHA DE L'ACIDE RÉTINOÏQUE ET D'UN ANTICORPS ANTI-CD38
Abstract:
(EN) The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists in combination with another therapy, more specifically an anti-CD38 therapy. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such combination therapy is suitable for use in treatment.
(FR) L'invention concerne des méthodes qui définissent des populations cellulaires sensibles aux agonistes RARA et identifient des sous-groupes de patients qui bénéficieront d'un traitement avec des agonistes RARA en combinaison avec une autre thérapie, plus spécifiquement une thérapie anti-CD38. L'invention concerne également des compositions pharmaceutiques conditionnées qui comprennent un agoniste RARA et des instructions pour déterminer si cette polythérapie est appropriée pour être utilisée dans un traitement.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)