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1. (WO2018067935) METHODS AND KITS FOR DETECTING A FUSION MESSENGER RNA TRANSCRIPT OR A POLYPEPTIDE ENCODED BY THE FUSION MESSENGER RNA TRANSCRIPT

Pub. No.:    WO/2018/067935    International Application No.:    PCT/US2017/055542
Publication Date: Fri Apr 13 01:59:59 CEST 2018 International Filing Date: Sat Oct 07 01:59:59 CEST 2017
IPC: A01N 37/18
A01N 43/04
A61K 38/00
A61P 1/00
A61P 37/02
A61P 37/04
Applicants: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors: MIDDLETON, Frank
KERR, William, G.
DENNEY, Sandra, Fernandes
Title: METHODS AND KITS FOR DETECTING A FUSION MESSENGER RNA TRANSCRIPT OR A POLYPEPTIDE ENCODED BY THE FUSION MESSENGER RNA TRANSCRIPT
Abstract:
The present invention relates to methods and kits for detecting a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript. The method includes obtaining a biological sample from a subject and providing one or more reagents capable of binding a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript, wherein the fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript comprises the 3' end of ex on 25 of INPP5D fused to the 5' end of ex on 2 of ATG16L1 or the polypeptide encoded by the 3' end of ex on 25 of INPP5D fused to the 5' end of ex on 2 of ATG16L1, respectively.