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1. (WO2018067935) METHODS AND KITS FOR DETECTING A FUSION MESSENGER RNA TRANSCRIPT OR A POLYPEPTIDE ENCODED BY THE FUSION MESSENGER RNA TRANSCRIPT
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Pub. No.: WO/2018/067935 International Application No.: PCT/US2017/055542
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
IPC:
A01N 37/18 (2006.01) ,A01N 43/04 (2006.01) ,A61K 38/00 (2006.01) ,A61P 1/00 (2006.01) ,A61P 37/02 (2006.01) ,A61P 37/04 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
37
Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
18
containing the group -CO-N, e.g. carboxylic acid amides or imides; Thio-analogues thereof
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02
having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
04
with one hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
04
Immunostimulants
Applicants: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK[US/US]; 750 East Adams Street Syracure, NY 13210, US
Inventors: MIDDLETON, Frank; US
KERR, William, G.; US
DENNEY, Sandra, Fernandes; US
Agent: GOLDMAN, Michael, L.; US
MERKEL, Edwin, V.; US
TISCHNER, Tate, L.; US
CHILDS, Carissa, R.; US
O'GARA, Megan, T.; US
Priority Data:
62/404,86206.10.2016US
Title (EN) METHODS AND KITS FOR DETECTING A FUSION MESSENGER RNA TRANSCRIPT OR A POLYPEPTIDE ENCODED BY THE FUSION MESSENGER RNA TRANSCRIPT
(FR) PROCÉDÉS ET KITS PERMETTANT DE DÉTECTER UN PRODUIT DE TRANSCRIPTION D'ARN MESSAGER DE FUSION OU UN POLYPEPTIDE CODÉ PAR LE PRODUIT DE TRANSCRIPTION D'ARN MESSAGER DE FUSION
Abstract:
(EN) The present invention relates to methods and kits for detecting a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript. The method includes obtaining a biological sample from a subject and providing one or more reagents capable of binding a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript, wherein the fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript comprises the 3' end of ex on 25 of INPP5D fused to the 5' end of ex on 2 of ATG16L1 or the polypeptide encoded by the 3' end of ex on 25 of INPP5D fused to the 5' end of ex on 2 of ATG16L1, respectively.
(FR) La présente invention se rapporte à des procédés et à des kits permettant de détecter un produit de transcription d'ARNm de fusion ou un polypeptide codé par le produit de transcription d'ARNm de fusion. Le procédé consiste à obtenir un échantillon biologique d'un sujet et à fournir un ou plusieurs réactifs qui peuvent lier un produit de transcription d'ARNm de fusion ou un polypeptide codé par le produit de transcription d'ARNm de fusion, le produit de transcription d'ARNm de fusion ou le polypeptide codé par le produit de transcription d'ARNm de fusion comprenant l'extrémité 3' d'ex sur 25 de INPP5D fusionnée à l'extrémité 5' d'ex sur 2 de ATG16L1 ou le polypeptide codé par l'extrémité 3' d'ex sur 25 de INPP5D fusionnée à l'extrémité 5' d'ex sur 2 de ATG16L1, respectivement.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)