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1. (WO2018067826) GENERATING MATURE LINEAGES FROM INDUCED PLURIPOTENT STEM CELLS WITH MECP2 DISRUPTION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/067826    International Application No.:    PCT/US2017/055353
Publication Date: 12.04.2018 International Filing Date: 05.10.2017
IPC:
C12N 5/0783 (2010.01), C12N 5/0784 (2010.01), C12N 5/0789 (2010.01), C12N 15/85 (2006.01)
Applicants: FUJIFILM CELLULAR DYNAMICS, INC. [US/US]; 525 Science Drive Suite 200 Madison, WI 53711 (US)
Inventors: RAJESH, Deepika; (US).
STROUSE, Anne; (US).
BURTON, Sarah; (US).
MUNN, Christie; (US).
SWANSON, Bradley; (US)
Agent: MANN, Monica; (US)
Priority Data:
62/404,430 05.10.2016 US
Title (EN) GENERATING MATURE LINEAGES FROM INDUCED PLURIPOTENT STEM CELLS WITH MECP2 DISRUPTION
(FR) GÉNÉRATION DE LIGNÉES MATURES À PARTIR DE CELLULES SOUCHES PLURIPOTENTES INDUITES AVEC UNE INTERRUPTION MECP2
Abstract: front page image
(EN)Provided herein are methods for the efficient in vitro maintenance, expansion, culture, and/or differentiation of pluripotent cells with disruption of the MeCP2 gene into various erythroid, myeloid, lymphoid, or endoderm lineages, particularly mature erythrocytes. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the precursor cells.
(FR)L'invention concerne des procédés pour le maintien, l'expansion, la culture, et/ou la différenciation in vitro efficaces de cellules pluripotentes avec une interruption du gène MeCP2 dans diverses lignées érythroïdes, myéloïdes, lymphoïdes ou endodermiques, en particulier les érythrocytes matures. Les cellules pluripotentes peuvent être maintenues et différenciées sous des conditions définies; ainsi, l'utilisation de cellules nourricières de souris ou de sérum n'est pas requise dans certains modes de réalisation pour la différenciation des cellules précurseurs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)