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1. (WO2018067717) AMINO ACID COMPOSITIONS AND USES THEREOF
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Pub. No.: WO/2018/067717 International Application No.: PCT/US2017/055167
Publication Date: 12.04.2018 International Filing Date: 04.10.2017
IPC:
A61K 31/195 (2006.01) ,A61K 31/197 (2006.01) ,A61K 31/198 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
Applicants:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED [US/US]; 223 Grinter Hall Gainesville, FL 32611, US
ENTRINSIC HEALTH SOLUTIONS, INC.; 100 River Ridge Drive Suite 206 Norwood, MA 02062, US
Inventors:
VIDYASAGAR, Sadasivan; US
GUPTA, Reshu; US
YIN, Lianjie; US
GROSCHE, Astrid; US
OKUNIEFF, Paul, Gerson; US
GATTO, Stephen; US
DENNISON, Daniel; US
Agent:
CHAO, Jessica, J.; US
Priority Data:
62/403,96504.10.2016US
62/421,44314.11.2016US
Title (EN) AMINO ACID COMPOSITIONS AND USES THEREOF
(FR) COMPOSITIONS D'ACIDES AMINÉS ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) The present disclosure provides compositions and methods for promoting stem cell and/or progenitor cell proliferation and/or differentiation. The provided compositions may be useful in treating a disease or condition that is related to mucosal barrier function, e.g., wound healing, treating skin conditions (e.g., atopic dermatitis, psoriasis, bed sores, or condition related to the aging of skin), treating a lung disorders (e.g., asthma), a condition related to improving mucosal barrier function, and/or treating injury to GI mucosa in a subject in need thereof. The present disclosure also provides methods for promoting the proliferation and/or differentiation of stem cells and/or the progenitor cells in a subject in need of such treatment by administering a composition. The ability to stimulate the proliferation and/or differentiation of stem cells and/or the progenitor cells in vivo, ex vivo and/or in vitro provides tremendous benefit. The present disclosure can be used to increase stem cell populations in in vivo, ex vivo and/or in vitro. Stem cell transplantation provides treatments and/or cures of many disease states, degeneration and/or injury.
(FR) La présente invention concerne des compositions et des méthodes destinées à favoriser la prolifération et/ou la différenciation de cellules souches et/ou de cellules progénitrices. Les compositions selon l'invention peuvent être utiles dans le traitement d'une maladie ou d'un état pathologique lié à une fonction de barrière muqueuse, par exemple, la cicatrisation de plaie, le traitement d'états pathologiques cutanés (, par exemple, la dermatite atopique, le psoriasis, les escarres de décubitus, ou un état pathologique lié au vieillissement de la peau), le traitement d'un trouble pulmonaire (, par exemple, l'asthme), d'un état lié à l'amélioration de la fonction barrière des muqueuses, et/ou le traitement d'une lésion à la muqueuse gastro-intestinale chez un sujet ayant besoin d'un tel traitement. La présente invention concerne également des méthodes destinées à favoriser la prolifération et/ou la différenciation de cellules souches et/ou de cellules progénitrices chez un sujet ayant besoin d'un tel traitement par le biais de l'administration d'une composition. La capacité de stimulation de la prolifération et/ou la différenciation de cellules souches et/ou de cellules progénitrices in vivo, ex vivo et/ou in vitro permet d'obtenir un bénéfice extrêmement significatif. La présente invention peut être utilisée pour augmenter des populations de cellules souches in vivo, ex vivo et/ou in vitro. La transplantation de cellules souches fournit des traitements et/ou des remèdes pour de nombreux états pathologiques, dégénérescences et/ou lésions.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)