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1. (WO2018067589) ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES

Pub. No.:    WO/2018/067589    International Application No.:    PCT/US2017/054969
Publication Date: Fri Apr 13 01:59:59 CEST 2018 International Filing Date: Wed Oct 04 01:59:59 CEST 2017
IPC: C07D 217/26
A61K 31/5377
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
NY STATE PSYCHIATRIC INSTITUTE
Inventors: RINDERSPACHER, Kirsten, Alison
YU, Wai
DUFF, Karen
LANDRY, Donald
DENG, Shi-xian
Title: ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES
Abstract:
The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.