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1. (WO2018067434) IDENTIFICATION AND USE OF VERY LONG CHAIN DICARBOXYLIC ACIDS FOR DISEASE DIAGNOSIS, CHEMOPREVENTION, AND TREATMENT
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Pub. No.: WO/2018/067434 International Application No.: PCT/US2017/054713
Publication Date: 12.04.2018 International Filing Date: 02.10.2017
IPC:
G01N 33/86 (2006.01)
Applicants: LINCOLN MEMORIAL UNIVERSITY[US/US]; 6965 Cumberland Gap Parkway Harrogate, Tennessee 37752, US
Inventors: WOOD, Paul L.; US
Agent: BLANCHARD, Jonathan M.; US
LAKE, Andrew C.; US
PITTS, Robert E.; US
HORTON, Jacob G.; US
JONES, Thomas L.; US
STEPHENS, Raymond E.; US
ARNOLD, Adam; US
FORSYTH, Paul A.; US
Priority Data:
15/284,21903.10.2016US
Title (EN) IDENTIFICATION AND USE OF VERY LONG CHAIN DICARBOXYLIC ACIDS FOR DISEASE DIAGNOSIS, CHEMOPREVENTION, AND TREATMENT
(FR) IDENTIFICATION ET UTILISATION D'ACIDES DICARBOXYLIQUES À CHAÎNE TRÈS LONGUE POUR LE DIAGNOSTIC, LA CHIMIOPRÉVENTION ET LE TRAITEMENT DE MALADIES
Abstract: front page image
(EN) A method for determining colorectal cancer risk includes obtaining a blood sample of the subject, isolating serum or EDTA plasma from the blood sample, analyzing the serum or EDTA plasma to determine plasma levels of very long chain dicarboxylic acid (VLCDCA 28:4), comparing the determined plasmas level of VLCDCA 28:4 of the subject with a predetermined range of plasma levels of VLCDCA 28:4 of diagnosed subjects having colorectal cancer, and determining a colorectal cancer risk exists when the determined plasma level of VLCDCA 28:4 is within the predetermined range of plasma levels of VLCDCA.
(FR) Cette invention concerne un procédé de détermination du risque de cancer colorectal comprenant l'obtention d'un échantillon de sang du sujet, l'isolement du sérum ou du plasma sur EDTA à partir de l'échantillon de sang, l'analyse du sérum ou du plasma sur EDTA pour déterminer les niveaux plasmatiques d'acide dicarboxylique à chaîne très longue (VLCDCA 28:4), la comparaison du niveau plasmatique de VLCDCA 28:4 déterminé chez le sujet avec une plage prédéfinie de niveaux plasmatiques de VLCDCA 28:4 chez des sujets diagnostiqués comme ayant un cancer colorectal, et la détermination du risque de cancer colorectal quand le niveau plasmatique de VLCDCA 28:4 déterminé s'inscrit dans la plage prédéfinie des niveaux plasmatiques de VLCDCA.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)