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1. WO2018067432 - IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES

Publication Number WO/2018/067432
Publication Date 12.04.2018
International Application No. PCT/US2017/054710
International Filing Date 02.10.2017
IPC
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/5025 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61K 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
37Medicinal preparations containing proteinaceous materials, lipoids, or derivatives thereof
02Proteins; Peptides; Peptones
CPC
A61K 31/5025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • BRISTOL-MYERS SQUIBB COMPANY [US]/[US]
Inventors
  • SPERGEL, Steven, H.
  • MERTZMAN, Michael, E.
Agents
  • KORSEN, Elliott
  • CLAUSS, Isabelle M.
  • DELAUNEY, Ashton J.
  • FARQUHARSON TORRES, Serena
  • GOLIAN, Paul D.
  • GREENBLATT, Gary D.
  • GUO, Z., Angela
  • HADAD, Henry
  • HAN, Bo
  • JACOBSEN, Barry
  • LIU, Hong
  • LU, Yong
  • PARLET, Nickki, L.
  • SUN, Jing
  • VANATTEN, Mary, K.
  • VOM WEGE, Julia
  • WALSH, Brian, J.
  • EPPERSON, James
  • MINGO, Pamela, A.
  • BELLOMY, Gregory, R.
  • CHAO, Yuan
  • HAI, Bing
Priority Data
62/405,30907.10.2016US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
(FR) COMPOSÉS IMIDAZOPYRIDAZINE UTILES EN TANT QUE MODULATEURS DE RÉPONSES IL-12, IL-23 ET/OU IFN ALPHA
Abstract
(EN) Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of formula I are useful for the treatment of inflammatory or autoimmune diseases.
(FR) La présente invention concerne des composés de formule I ou un stéréoisomère ou sel pharmaceutiquement acceptable de ceux-ci, qui sont utiles dans la modulation d'IL -12, IL -23 et/ou IFNα, en agissant sur Tyk -2 pour provoquer l'inhibition de la transduction du signal. Les composés de formule I sont utiles pour le traitement de maladies inflammatoires ou auto-immunes.
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