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1. (WO2018067432) IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/067432    International Application No.:    PCT/US2017/054710
Publication Date: 12.04.2018 International Filing Date: 02.10.2017
IPC:
C07D 487/04 (2006.01), A61K 31/5025 (2006.01), A61P 29/00 (2006.01), A61K 37/02
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and ProvinceLine Road Princeton, NJ 08543 (US)
Inventors: SPERGEL, Steven, H.; (US).
MERTZMAN, Michael, E.; (US)
Agent: KORSEN, Elliott; (US).
CLAUSS, Isabelle M.; (US).
DELAUNEY, Ashton J.; (US).
FARQUHARSON TORRES, Serena; (US).
GOLIAN, Paul D.; (US).
GREENBLATT, Gary D.; (US).
GUO, Z., Angela; (US).
HADAD, Henry; (US).
HAN, Bo; (US).
JACOBSEN, Barry; (US).
LIU, Hong; (US).
LU, Yong; (US).
PARLET, Nickki, L.; (US).
SUN, Jing; (US).
VANATTEN, Mary, K.; (US).
VOM WEGE, Julia; (US).
WALSH, Brian, J.; (US).
EPPERSON, James; (US).
MINGO, Pamela, A.; (US).
BELLOMY, Gregory, R.; (US).
CHAO, Yuan; (US).
HAI, Bing; (US)
Priority Data:
62/405,309 07.10.2016 US
Title (EN) IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
(FR) COMPOSÉS IMIDAZOPYRIDAZINE UTILES EN TANT QUE MODULATEURS DE RÉPONSES IL-12, IL-23 ET/OU IFN ALPHA
Abstract: front page image
(EN)Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of formula I are useful for the treatment of inflammatory or autoimmune diseases.
(FR)La présente invention concerne des composés de formule I ou un stéréoisomère ou sel pharmaceutiquement acceptable de ceux-ci, qui sont utiles dans la modulation d'IL -12, IL -23 et/ou IFNα, en agissant sur Tyk -2 pour provoquer l'inhibition de la transduction du signal. Les composés de formule I sont utiles pour le traitement de maladies inflammatoires ou auto-immunes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)