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1. (WO2018067291) IDENTIFICATION AND GENERATION OF PERSONALIZED VACCINE COMPONENTS BY FUNCTIONAL SCREENING VARIABLE EPITOPE AND MIMOTOPE LIBRARIES

Pub. No.:    WO/2018/067291    International Application No.:    PCT/US2017/051845
Publication Date: Fri Apr 13 01:59:59 CEST 2018 International Filing Date: Sat Sep 16 01:59:59 CEST 2017
IPC: A61K 39/00
C40B 30/06
C40B 40/10
C07K 4/00
C07K 7/00
C12N 5/0783
Applicants: PRIMEX CLINICAL LABORATORIES
Inventors: MANUCHARYAN, Karen
Title: IDENTIFICATION AND GENERATION OF PERSONALIZED VACCINE COMPONENTS BY FUNCTIONAL SCREENING VARIABLE EPITOPE AND MIMOTOPE LIBRARIES
Abstract:
Specifically, methods for patient stratification and selection of personalized peptide based treatments and vaccines are disclosed, including assays for identifying antigenic and immunogenic peptides involved in immune responses of mammals against pathogens, cancer and other diseases by interrogating the T lymphocyte repertoire of a patient using combinatorial T-cell epitope and mimotope libraries.