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1. (WO2018067075) COMPOSITIONS AND METHODS FOR PROTEIN EXPRESSION AND DELIVERY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/067075    International Application No.:    PCT/SG2017/050505
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
IPC:
C07K 14/47 (2006.01), A61K 9/51 (2006.01)
Applicants: NATIONAL UNIVERSITY OF SINGAPORE [SG/SG]; 21 Lower Kent Ridge Road, Singapore 119077 (SG)
Inventors: DRUM, Chester Lee; (SG).
MASURKAR, Nihar; (SG).
DESHPANDE, Siddharth; (SG).
CHAKRABORTY, Goutam; (SG).
VALLERINTEAVIDE MAVELLI, Girish; (SG)
Agent: MATTEUCCI, Gianfranco; (SG)
Priority Data:
62/405,613 07.10.2016 US
Title (EN) COMPOSITIONS AND METHODS FOR PROTEIN EXPRESSION AND DELIVERY
(FR) COMPOSITIONS ET PROCÉDÉS D'EXPRESSION ET D'ADMINISTRATION DE PROTÉINES
Abstract: front page image
(EN)The present invention relates to methods and compositions that provide an environment that promotes enhanced protein expressing and/or folding. More particularly, the present invention provides engineered thermostable ferritin assemblies comprising at least one modified ferritin subunit, wherein the least at least one modified ferritin subunit lacks an unstructured carboxy-terminal sequence that is present in a wildtype ferritin subunit and wherein the engineered assembly is stable at lower salt concentrations that a wildtype ferritin assembly. The invention is exemplified by a ferritin assembly derived from hyperthermophilic Archaeoglobus fulgidus. Also claimed are nucleic acids, compositions, kits and methods of encapsulating a polypeptide, delivering and administering the said engineered ferritin assembly to a subject.
(FR)La présente invention concerne des procédés et des compositions qui fournissent un environnement qui favorise une expression et/ou un repliement de protéines améliorés. Plus particulièrement, la présente invention concerne des ensembles de ferritine thermostables modifiés comprenant au moins une sous-unité de ferritine modifiée, au moins une sous-unité de ferritine modifiée étant dépourvue d'une séquence carboxy-terminale non structurée qui est présente dans une sous-unité de ferritine de type sauvage et l'ensemble modifié étant stable à des concentrations de sel plus faibles qu'un ensemble de ferritine de type sauvage. L'invention est illustrée par un ensemble de ferritine issu de l'hyperthermophile Archaeoglobus fulgidus. L'invention concerne également des acides nucléiques, des compositions, des kits et des procédés d'encapsulation d'un polypeptide, l'administration et l'introduction dudit ensemble de ferritine modifié à un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)