Search International and National Patent Collections

1. (WO2018066999) CHIMERIC ENTEROVIRUS VIRUS-LIKE PARTICLES

Pub. No.:    WO/2018/066999    International Application No.:    PCT/MY2017/050059
Publication Date: Fri Apr 13 01:59:59 CEST 2018 International Filing Date: Fri Sep 22 01:59:59 CEST 2017
IPC: A61K 39/125
A61K 39/135
Applicants: SENTINEXT THERAPEUTICS SDN BHD
Inventors: CARDOSA, Mary Jane
Title: CHIMERIC ENTEROVIRUS VIRUS-LIKE PARTICLES
Abstract:
The invention provides chimeric Enterovirus virus-like particles (VLPs) for protection and/or treatment against infection by more than one Enterovirus. More specifically, the present invention provides chimeric EV-A71 virus-like particles displaying CV-A16 VP1 polypeptides and at the same time maintaining important neutralizing antibody epitopes of EV-A71 itself. More specifically, the present invention provides chimeric CV-A16 virus-like particles displaying EV-A71 VP1 polypeptides. Thus, the present invention provides a bivalent vaccine comprising the chimeric virus-like particles which elicit an immune response and/or neutralizing antibody response to both EV-A71 and CVA-16 for the treatment of Hand, Foot and Mouth Disease.