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1. (WO2018066948) RECOMBINANT ANTIGEN PROTEIN COMPOSED OF MULTIPLE EPITOPES AND METHOD FOR PRODUCING SAME

Pub. No.:    WO/2018/066948    International Application No.:    PCT/KR2017/011027
Publication Date: Fri Apr 13 01:59:59 CEST 2018 International Filing Date: Sat Sep 30 01:59:59 CEST 2017
IPC: A61K 39/135
A61K 39/00
Applicants: SNU R&DB FOUNDATION
서울대학교산학협력단
Inventors: CHOI, Yun Jaie
최윤재
KANG, Sang Kee
강상기
CHO, Chong Su
조종수
LEE, Ho Bin
이호빈
Title: RECOMBINANT ANTIGEN PROTEIN COMPOSED OF MULTIPLE EPITOPES AND METHOD FOR PRODUCING SAME
Abstract:
The present invention relates to a recombinant antigen protein composed of multiple epitopes in order to develop a foot-and-mouth disease subunit vaccine and a method for producing the same. A recombinant expression vector according to the present invention can mass-produce recombinant antigen proteins inexpensively and safely through microorganism culture and can be easily purified. It is confirmed that the recombinant antigen protein produced by the recombinant expression vector is composed as a multi-epitope to improve immune responses against various foot-and-mouth disease variants. Therefore, the recombinant expression vector can be advantageously used as a tool for providing a recombinant antigen protein that can be used as an effective foot-and-mouth disease subunit vaccine.