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1. (WO2018066646) UREA DERIVATIVE

Pub. No.:    WO/2018/066646    International Application No.:    PCT/JP2017/036272
Publication Date: Fri Apr 13 01:59:59 CEST 2018 International Filing Date: Fri Oct 06 01:59:59 CEST 2017
IPC: A61K 31/198
A61K 31/381
A61K 31/40
A61K 31/4453
A61P 13/12
A61P 43/00
C07C 275/28
C07C 275/30
C07C 275/34
C07C 275/42
C07C 323/44
C07D 207/10
C07D 295/135
C07D 333/36
Applicants: DAIICHI SANKYO COMPANY,LIMITED
第一三共株式会社
Inventors: SONEDA, Tsuyoshi
曽根田 剛
NAKAMURA, Yuji
中村 勇二
MATSUMOTO, Koji
松本 康嗣
TANAKA, Naomi
田中 奈緒美
FUKUNAGA, Taichi
福永 大地
Title: UREA DERIVATIVE
Abstract:
The present invention addresses the problem of finding a novel medicine which has an excellent tryptophanase inhibitory effect, suppresses indoxyl sulfate production in blood to thereby prevent deterioration of renal function, and thus contributes to kidney preservation. Provided is a medicinal composition which comprises a compound represented by the formula or a pharmacologically acceptable salt thereof as an active ingredient. (In the formula: R1 and R2 may be the same or different and represent a C1-C6 alkyl group, etc.; and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.)