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1. (WO2018065972) METHOD OF ISOLATING BOTULINUM TOXIN FROM BOTULINUM TOXIN-CONTAINING SOLUTION
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Pub. No.: WO/2018/065972 International Application No.: PCT/IB2017/057476
Publication Date: 12.04.2018 International Filing Date: 29.11.2017
IPC:
C07K 1/18 (2006.01) ,C07K 14/33 (2006.01) ,B01D 15/36 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
16
by chromatography
18
Ion-exchange chromatography
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
33
from Clostridium (G)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
15
Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08
Selective adsorption, e.g. chromatography
26
characterised by the separation mechanism
36
involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
Applicants:
MEDYTOX INC. [KR/KR]; 78, Gangni 1-gil, Ochang-eup Cheongwon-gu, Cheongju-si Chungcheongbuk-do 28126, KR
Inventors:
JUNG, Hyun Ho; KR
YANG, Gi Hyeok; KR
RHEE, Chang Hoon; KR
KIM, Hack Woo; KR
RYU, Gi Hyuck; KR
HONG, Hyung Pyo; KR
SONG, Jung Hyun; KR
KONG, Joon Chan; KR
Agent:
Y.P.LEE, MOCK & PARTNERS; 12F Daelim Acrotel, 13 Eonju-ro 30-gil Gangnam-gu Seoul 06292, KR
Priority Data:
10-2016-012754004.10.2016KR
Title (EN) METHOD OF ISOLATING BOTULINUM TOXIN FROM BOTULINUM TOXIN-CONTAINING SOLUTION
(FR) PROCÉDÉ D'ISOLEMENT DE TOXINE BOTULIQUE À PARTIR D'UNE SOLUTION CONTENANT UNE TOXINE BOTULIQUE
Abstract:
(EN) Provided is a method of isolating a botulinum toxin type A macro complex from a botulinum toxin-containing solution, the method including performing anion exchange chromatography and cation exchange chromatography.
(FR) L'invention concerne un procédé d'isolement d'un macrocomplexe de type A de toxine botulique à partir d'une solution contenant une toxine botulique, le procédé comprenant la mise en oeuvre d'une chromatographie par échange d'anions et d'une chromatographie par échange de cations.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)