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1. (WO2018065953) PHARMACEUTICAL SUSPENSION DOSAGE FORM OF BENZIMIDAZOLE COMPOUNDS AND PROCESS OF PREPARATION THEREOF
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Pub. No.: WO/2018/065953 International Application No.: PCT/IB2017/056183
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
IPC:
C07D 401/00 (2006.01) ,A61K 9/00 (2006.01) ,A61K 9/16 (2006.01) ,A61K 31/4439 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
Applicants:
JUBILANT GENERICS LIMITED [IN/IN]; Plot 1A, Sector 16A, Noida 201 301, IN
Inventors:
MEHTA, Kamal Surendrakumar; IN
KUMAR, Dinesh; IN
SRIVASTAVA, Saurabh; IN
PAUL, Basudev; IN
Agent:
SINGH, Manisha; IN
Priority Data:
20161103427006.10.2016IN
Title (EN) PHARMACEUTICAL SUSPENSION DOSAGE FORM OF BENZIMIDAZOLE COMPOUNDS AND PROCESS OF PREPARATION THEREOF
(FR) FORME POSOLOGIQUE PHARMACEUTIQUE EN SUSPENSION DE COMPOSÉS DE BENZIMIDAZOLE ET SON PROCÉDÉ DE PRÉPARATION
Abstract:
(EN) The present invention relates to a solid oral pharmaceutical dosage form suitable for making a suspension comprising acid labile benzimidazole compounds and process for preparing the same. The prior art discloses various technical challenges associated with the granules for reconstitution into suspension like agglomeration of particles, viscosity and gelling time. The solid oral pharmaceutical dosage form of the present invention forms a homogeneous suspension upon admixing with an aqueous medium and exhibits desired technical attributes like viscosity, drug release, gelling time, dissolution and reduced adherence to nasogastric and gastric tubes.
(FR) La présente invention concerne une forme posologique pharmaceutique orale solide appropriée pour fabriquer une suspension comprenant des composés de benzimidazole acido-labiles et son procédé de préparation. L'état de la technique décrit divers défis techniques associés aux granules pour la reconstitution en suspension comme l'agglomération de particules, la viscosité et le temps de gélification. La forme posologique pharmaceutique orale solide de la présente invention reconstitue une suspension homogène lors du mélange avec un milieu aqueux et présente des attributs techniques souhaités comme la viscosité, la libération de médicament, le temps de gélification, la dissolution et l'adhérence réduite aux tubes nasogastriques et gastriques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)