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1. (WO2018065887) COMPOSITIONS, DEVICES AND METHODS FOR THE CONTROL IN VITRO OF CHEMICAL MICROAMBIENT IN CELL CULTURES

Pub. No.:    WO/2018/065887    International Application No.:    PCT/IB2017/056081
Publication Date: Fri Apr 13 01:59:59 CEST 2018 International Filing Date: Wed Oct 04 01:59:59 CEST 2017
IPC: C12N 5/071
C12N 5/09
C12N 11/02
C12N 11/06
Applicants: ALMA MATER STUDIORUM - UNIVERSITÀ DI BOLOGNA
Inventors: RAPINO, Stefania
ZERBETTO, Francesco
CASTELLANI, Gastone
SALVIOLI, Stefano
FRABONI, Beatrice
ZIRONI, Isabella
CONTE, Maria
FRANCESCHI, Claudio
SALVATORE, Daniela
BECCONI, Maila
Title: COMPOSITIONS, DEVICES AND METHODS FOR THE CONTROL IN VITRO OF CHEMICAL MICROAMBIENT IN CELL CULTURES
Abstract:
The present invention relates to compositions comprising a polymeric matrix or a gel containing functional enzymes capable of re-creating under culture conditions the cell microenvironment existing in vivo. The present invention also relates to devices for cell cultures comprising such compositions, in particular hydrogel and the use thereof to control the chemical microenvironment of a cell culture or mimic physiological or pathological conditions of the in vivo cells. The compositions and the devices described herein could be also used in vitro for evaluating the therapeutic effect of a compound on a determined cell line or on primary cells.