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Pub. No.:    WO/2018/065787    International Application No.:    PCT/GB2017/053033
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
C07D 405/12 (2006.01), A61K 31/4709 (2006.01), A61P 35/00 (2006.01)
Applicants: CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Angel Building 407 St John Street London EC1V 4AD (GB)
Inventors: JONES, Keith; (GB).
CHEESEMAN, Matthew D.; (GB).
PASQUA, A. Elisa; (GB).
TUCKER, Michael J.; (GB)
Agent: HGF LIMITED; 4th Floor, Merchant Exchange 17-19 Whitworth Street West Manchester M1 5WG (GB)
Priority Data:
1617103.5 07.10.2016 GB
Abstract: front page image
(EN)The present invention relates to N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1-yl)methyl)quinoline-6-carboxamide, or a pharmaceutically acceptable salt or solvate thereof, wherein at least one hydrogen atom has been substituted with a deuterium atom. Other aspects include pharmaceutical compositions comprising said compounds and medical uses and methods of treatment using said compounds.
(FR)La présente invention concerne un composé N- (5- (2,3-dihydrobenzo [b] [1,4] dioxine-6-carboxamido)-2-fluorophényl)-2-((4-éthylpipérazin-1-yl) méthyl) quinoléine-6-carboxamide, ou un sel ou solvate pharmaceutiquement acceptable de celui-ci, au moins un atome d'hydrogène ayant été substitué par un atome de deutérium. D'autres aspects comprennent des compositions pharmaceutiques comprenant lesdits composés et des utilisations médicales et des procédés de traitement utilisant lesdits composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)