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1. (WO2018065622) IMMUNOSUPPRESSION-REVERTING OLIGONUCLEOTIDES INHIBITING THE EXPRESSION OF CD39

Pub. No.:    WO/2018/065622    International Application No.:    PCT/EP2017/075647
Publication Date: Fri Apr 13 01:59:59 CEST 2018 International Filing Date: Tue Oct 10 01:59:59 CEST 2017
IPC: C12N 15/113
A61K 31/712
A61K 31/7125
C07H 21/00
Applicants: SECARNA PHARMACEUTICALS GMBH & CO. KG
Inventors: JASCHINSKI, Frank
HILMENYUK, Tamara
Title: IMMUNOSUPPRESSION-REVERTING OLIGONUCLEOTIDES INHIBITING THE EXPRESSION OF CD39
Abstract:
The present invention refers to immunosuppression-reverting oligonucleotides comprising 12 to 18 nucleotides, wherein at least one of the nucleotides is modified, and the oligonucleotide hybridizes with a nucleic acid sequence of an ectonucleotidase (NTPdase; CD73) of SEQ ID NO.1 (human), wherein the oligonucleotide inhibits at least 50 % of the CD39 expression. The invention is further directed to a pharmaceutical composition comprising such oligonucleotide.