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1. (WO2018065599) MULTI-PROTEASE METHOD
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Pub. No.: WO/2018/065599 International Application No.: PCT/EP2017/075532
Publication Date: 12.04.2018 International Filing Date: 06.10.2017
Chapter 2 Demand Filed: 06.08.2018
IPC:
G01N 33/68 (2006.01) ,C07K 7/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
Applicants:
OBLIQUE THERAPEUTICS AB [SE/SE]; Arvid Wallgrens backe 20 41346 Göteborg, SE
Inventors:
ORWAR, Owe; SE
TRKULJA, Carolina; SE
DAVIDSON, Max; SE
HÄGGLUND, Jessica; SE
Agent:
OWEN, Deborah; GB
Priority Data:
1617002.906.10.2016GB
Title (EN) MULTI-PROTEASE METHOD
(FR) PROCÉDÉ MULTI-PROTÉASE
Abstract:
(EN) The present invention relates to methods of identifying an epitope on a protein that can be bound by an antibody. Methods of the invention typically involve a step of limited or restricted proteolysis of a protein using a single first protease or a combination of first proteases, and a further proteolysis step using a single second protease or combination of second proteases. The invention also relates to identified epitopes and to antibodies which bind to epitopes that have been identified by methods of the invention.
(FR) La présente invention concerne des procédés d'identification d'un épitope présent sur une protéine auquel un anticorps peut se lier. Les procédés selon l'invention impliquent généralement une étape de protéolyse limitée ou restreinte d'une protéine à l'aide d'une première protéase unique ou d'une combinaison de premières protéases, et une étape de protéolyse supplémentaire à l'aide d'une seconde protéase unique ou d'une combinaison de secondes protéases. Des épitopes identifiés et des anticorps qui se lient aux épitopes qui ont été identifiés par les procédés selon l'invention sont en outre décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)