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1. (WO2018064851) USE OF LOW-DOSE SILDENAFIL AS ANTITUMOR DRUG

Pub. No.:    WO/2018/064851    International Application No.:    PCT/CN2016/103957
Publication Date: Fri Apr 13 01:59:59 CEST 2018 International Filing Date: Tue Nov 01 00:59:59 CET 2016
IPC: A61K 31/519
A61P 35/00
Applicants: GUANGZHOU DAWNLIGHT BIOTECH COMPANY
广州市东来生物科技有限公司
Inventors: LIU, Yu
刘誉
Title: USE OF LOW-DOSE SILDENAFIL AS ANTITUMOR DRUG
Abstract:
The invention discloses a use of low-dose sildenafil as an antitumor drug. The chemical name of the sildenafil is 1-[4-ethoxy-3-[5-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolol[4,3d]pyrimidin)]phenylsulfonyl]-4-methylpiperazin citrate, and a using dosage of the sildenafil is 2-25 mg. Sildenafil citrate with an oral dose of 2-25 mg, an injection dose of 2-10 mg or an external application dose lower than 1% by mass can be used for the treatment of malignant tumor.