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1. (WO2018064755) COMPOSITIONS FOR TRANSFECTING RESISTANT CELL TYPES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/064755    International Application No.:    PCT/CA2017/051167
Publication Date: 12.04.2018 International Filing Date: 02.10.2017
IPC:
C12N 15/87 (2006.01), A61K 47/10 (2017.01), A61K 47/14 (2017.01), A61K 47/18 (2017.01), A61K 47/24 (2006.01), A61K 47/28 (2006.01), C07C 229/30 (2006.01), C07F 9/10 (2006.01), C12N 15/10 (2006.01), C12N 15/11 (2006.01), C12N 15/113 (2010.01), C12N 5/071 (2010.01), C07J 9/00 (2006.01)
Applicants: PRECISION NANOSYSTEMS INC. [CA/CA]; 655 West Kent Avenue N, Suite 50 Vancouver, British Columbia V6P6T7 (CA)
Inventors: THOMAS, Anitha; (CA).
DE SOUZA, Rebecca Anne Grace; (CA).
OUELLET, Eric; (CA).
THARMARAJAH, Grace Tharmini; (CA).
SINGH, Jagbir; (CA).
GARG, Shyam Madhusudan; (CA)
Agent: TEES, Susan; (CA)
Priority Data:
62/403,640 03.10.2016 US
Title (EN) COMPOSITIONS FOR TRANSFECTING RESISTANT CELL TYPES
(FR) COMPOSITIONS POUR LA TRANSFECTION DE TYPES DE CELLULES RÉSISTANTES
Abstract: front page image
(EN)A transfection reagent composition comprising: 30-60MOL% of an cationic lipid, or pharmaceutical acceptable salt thereof; 10-60 MOL% structural lipid; a sterol and 0.1 to about 10MOL% of a stabilizing agent is provided. The reagent is particularly adapted for neuron and related cell types. A method of manufacturing LNP including nucleic acid for selective uptake into either neurons or astrocytes or neural progenitor cells is also provided.
(FR)L'invention concerne une composition de réactif de transfection comprenant : 30-60 % en mole d'un lipide cationique ou d'un sel pharmaceutiquement acceptable correspondant ; 10-60 % en mole de lipide structural ; un stérol et 0,1 à environ 10 % en mole d'un agent de stabilisation. Le réactif est particulièrement approprié pour des types de neurones et de cellules associées. L'invention concerne également un procédé de production de nanoparticules lipidiques (LNP) comprenant un acide nucléique pour une absorption sélective dans des neurones ou des astrocytes ou des cellules progénitrices neurales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)