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1. (WO2018064654) PHARMACEUTICAL COMPOSITIONS COMPRISING A STATIN AND A CANNABINOID AND USES THEREOF
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Pub. No.: WO/2018/064654 International Application No.: PCT/US2017/054685
Publication Date: 05.04.2018 International Filing Date: 01.10.2017
IPC:
A61K 31/352 (2006.01) ,A61K 31/05 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols
Applicants:
SMEEDING, James [US/US]; US
SHERWOOD, Mathew [US/US]; US
Inventors:
SMEEDING, James; US
SHERWOOD, Mathew; US
Agent:
PECHENIK, Graham; US
Priority Data:
62/403,06701.10.2016US
Title (EN) PHARMACEUTICAL COMPOSITIONS COMPRISING A STATIN AND A CANNABINOID AND USES THEREOF
(FR) COMPOSITIONS PHARMACEUTIQUES COMPRENANT UNE STATINE ET UN CANNABINOÏDE ET LEURS UTILISATIONS
Abstract:
(EN) The invention relates to pharmaceutical compositions comprising a statin and a cannabinoid, and their use for the treatment of hypercholesterolemia and atherosclerosis. It has been found that compositions combining a statin and a cannabinoid are improved over existing statin formulations. The compositions of the invention for example allow for a lower effective dose of statin and a reduction of the adverse effects seen with statins taken alone. Dosing ranges and formulations suitable for oral, buccal, and sublingual administration are disclosed. Various specific cannabinoids such as cannabidiol and synthetic cannabidiols selected for their anti-inflammatory, antioxidant, and anti-atherosclerotic effect are shown to be particularly advantageous.
(FR) L'invention concerne des compositions pharmaceutiques comprenant une statine et un cannabinoïde, et leur utilisation pour le traitement de l'hypercholestérolémie et de l'athérosclérose. Il a été découvert que des compositions combinant une statine et un cannabinoïde sont améliorées par rapport aux formulations de statine existantes. Les compositions de l'invention permettent par exemple une dose efficace de statine inférieure et une réduction des effets indésirables observés avec les statines prises seules. L'invention concerne également des plages de dosage et des formulations appropriées pour une administration orale, buccale et sublinguale. Divers cannabinoïdes spécifiques tels que le cannabidiol et les cannabidiols synthétiques sélectionnés pour leur effet anti-inflammatoire, antioxydant et anti-athérosclérotique se montrent particulièrement avantageux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)