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1. (WO2018064648) OPHTHALMIC DRUG SUSTAINED RELEASE FORMULATION AND USES THEREOF

Pub. No.:    WO/2018/064648    International Application No.:    PCT/US2017/054654
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Sun Oct 01 01:59:59 CEST 2017
IPC: A61K 9/00
Applicants: MATI THERAPEUTICS INC.
UTKHEDE, Deepank
JONES, Catherine
WISEMAN, David
Inventors: UTKHEDE, Deepank
JONES, Catherine
WISEMAN, David
Title: OPHTHALMIC DRUG SUSTAINED RELEASE FORMULATION AND USES THEREOF
Abstract:
A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.