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1. (WO2018064629) METHODS FOR MULTI-RESOLUTION ANALYSIS OF CELL-FREE NUCLEIC ACIDS
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Pub. No.: WO/2018/064629 International Application No.: PCT/US2017/054607
Publication Date: 05.04.2018 International Filing Date: 29.09.2017
IPC:
C12Q 1/68 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
GUARDANT HEALTH, INC. [US/US]; 505 Penobscot Drive Redwood City, CA 94063, US
Inventors:
CHUDOVA, Darya; US
ELTOUKHY, Helmy; US
MORTIMER, Stefanie Ann, Ward; US
ABDUEVA, Diana; US
SIKORA, Marcin; US
Agent:
AMODEO, Gabriele, A.; US
ADVANI, Raj; US
ALMEDA, Dariela; US
AGRAWAL, Trisha; US
ALEMOZAFAR, Ali; US
Priority Data:
62/402,94030.09.2016US
62/468,20107.03.2017US
62/489,39124.04.2017US
Title (EN) METHODS FOR MULTI-RESOLUTION ANALYSIS OF CELL-FREE NUCLEIC ACIDS
(FR) PROCÉDÉS D'ANALYSE MULTIRÉSOLUTION D'ACIDES NUCLÉIQUES ACELLULAIRES
Abstract:
(EN) The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
(FR) La présente invention concerne un procédé permettant d'enrichir de multiples régions génomiques en utilisant un premier ensemble d'amorces qui s'hybride sélectivement à un premier ensemble de régions génomiques d'un échantillon d'acide nucléique et un second ensemble d'amorces qui s'hybride sélectivement à un second ensemble de régions génomiques de l'échantillon d'acide nucléique. Ces ensembles d'amorces peuvent enrichir sélectivement une ou plusieurs régions associées au nucléosome d'un génome, lesdites régions associées au nucléosome comprenant des régions génomiques ayant une ou plusieurs positions de base génomiques avec une occupation nucléosomique différentielle, l'occupation nucléosomique différentielle étant caractéristique d'un type de cellule ou de tissu d'origine ou malade.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)