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1. (WO2018064602) CHIMERIC ANTIGEN RECEPTOR THERAPY WITH REDUCED CYTOTOXICITY FOR VIRAL DISEASE

Pub. No.:    WO/2018/064602    International Application No.:    PCT/US2017/054556
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Sat Sep 30 01:59:59 CEST 2017
IPC: C07K 19/00
C12N 15/13
A61P 1/16
A61P 31/20
Applicants: BAYLOR COLLEGE OF MEDICINE
Inventors: KRUSE, Robert, Layne
BISSIG, Karl-Dimiter
GOTTSCHALK, Stephen, M.G.
SHUM, Thomas, C.T.
Title: CHIMERIC ANTIGEN RECEPTOR THERAPY WITH REDUCED CYTOTOXICITY FOR VIRAL DISEASE
Abstract:
Embodiments of the disclosure encompass immunotherapy for Hepatitis B viral (HBV) infection in an individual in need thereof. The immunotherapy comprises one or more chimeric antigen receptors (CAR) that target a HBV antigen, including CAR molecules that utilize specific scFv antibodies. In certain cases, the CAR comprises one or more mutations to reduce binding to Fc receptors. In specific aspects, cells that express the CAR(s) have reduced cytotoxicity that is safer and/or beneficial to individuals that are immunocompromised.