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1. (WO2018064578) HIGH-PRECISION DRUG DELIVERY BY DUAL-DOMAIN OCULAR DEVICE

Pub. No.:    WO/2018/064578    International Application No.:    PCT/US2017/054505
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Sat Sep 30 01:59:59 CEST 2017
IPC: A61F 9/00
A61K 9/22
A61K 9/52
G02C 7/04
Applicants: LYNTHERA CORPORATION
Inventors: YANG, Arthur Jing-Min
DOMSZY, Roman C.
YANG, Jeffry Chung-Hwang
Title: HIGH-PRECISION DRUG DELIVERY BY DUAL-DOMAIN OCULAR DEVICE
Abstract:
The present invention relates to a nanocomposite ocular device that can release drugs within a close distance to the ocular surface and provide controlled and sustained release of the drug at a constant rate. The device can achieve both optical and medical functions. The device comprises a drug, one or more reservoir domains, and a barrier layer configured to block the drug diffusion paths from the reservoir domain to the ocular surface in the eye of the subject, wherein the drug partitions between the reservoir domain and the barrier layer, and the equilibrium drug solubility in the reservoir domain is at least five folds higher than that in the barrier layer.