WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018064558) ZIKA VIRUS VACCINES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/064558 International Application No.: PCT/US2017/054469
Publication Date: 05.04.2018 International Filing Date: 29.09.2017
IPC:
A61K 39/12 (2006.01) ,A61P 31/14 (2006.01) ,C12N 15/62 (2006.01)
Applicants: GAMBOTTO, Andrea, A.[US/US]; US (US)
KIM, Eun[US/US]; US (US)
ERDOS, Geza[US/US]; US (US)
FALO, Louis, D., Jr.[US/US]; US (US)
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION[US/US]; 1st Floor Gardner Steel Conference Center 130 Thackeray Avenue Pittsburgh, PA 15260, US (AllExceptUS)
Inventors: GAMBOTTO, Andrea, A.; US
KIM, Eun; US
ERDOS, Geza; US
FALO, Louis, D., Jr.; US
Agent: SIEGEL, Susan, Alpert; US
Priority Data:
62/402,55730.09.2016US
62/460,50317.02.2017US
Title (EN) ZIKA VIRUS VACCINES
(FR) VACCINS CONTRE LE VIRUS ZIKA
Abstract:
(EN) Disclosed is an immunogen comprising a fusion protein, wherein the fusion protein comprises a Zika virus (ZIKV) envelope protein, optionally a signal peptide, and a multimerization domain. The signal peptide is a premembrane (prM) signal peptide, an IgG signal peptide, or a human secretory signal peptide hidden Markov model, and the multimerization domain is an immunoglobulin Fc domain, a T4 fibritin foldon trimerization domain, or a human collagen XV trimerization domain. Nucleic acids, vectors, and microneedle arrays including these compositions are disclosed. Methods of producing an immune response to ZIKV are also disclosed.
(FR) La présente invention concerne un immunogène comprenant une protéine de fusion, la protéine de fusion comprenant une protéine d’enveloppe du virus Zika (ZIKV), éventuellement un peptide signal, et un domaine de multimérisation. Le peptide signal est un peptide signal prémembranaire (prM), un peptide signal d’IgG, ou un modèle de Markov caché de peptide signal sécrétoire humain, et le domaine de multimérisation est un domaine (Fc) d’immunoglobuline, un domaine de trimérisation de foldon de la fibritine du phage (T4), ou un domaine de trimérisation de collagène humain (XV). La présente invention concerne également des acides nucléiques, des vecteurs, et des réseaux de microaiguilles comprenant ces compositions. La présente invention concerne également des procédés de production d’une réponse immunitaire au ZIKV.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)