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1. (WO2018064515) MICRORNA LET-7 AND TRANSFORMING GROWTH FACTOR BETA RECEPTOR III AXIS AS TARGET FOR CARDIAC INJURIES

Pub. No.:    WO/2018/064515    International Application No.:    PCT/US2017/054376
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Sat Sep 30 01:59:59 CEST 2017
IPC: A61K 39/395
A61K 48/00
A61K 39/00
Applicants: ACADEMIA SINICA
SHIH, Ming-Che
Inventors: HSIEH, Patrick, C.H.
CHEN, Chen-Yun
CHENG, Yu-Che
Title: MICRORNA LET-7 AND TRANSFORMING GROWTH FACTOR BETA RECEPTOR III AXIS AS TARGET FOR CARDIAC INJURIES
Abstract:
Methods for ameliorating cardiac injuries such as myocardial infarction by either enhancing the activity of a let-7 microRNA or inhibiting the activity of transformation growth factor beta receptor III (TGFBR3). Also provided herein are assay methods for detecting the level of TGFBR3, the level of a let-7 microRNA, or both in a biological sample.