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1. (WO2018064515) MICRORNA LET-7 AND TRANSFORMING GROWTH FACTOR BETA RECEPTOR III AXIS AS TARGET FOR CARDIAC INJURIES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/064515    International Application No.:    PCT/US2017/054376
Publication Date: 05.04.2018 International Filing Date: 29.09.2017
IPC:
A61K 39/395 (2006.01), A61K 48/00 (2006.01), A61K 39/00 (2006.01)
Applicants: ACADEMIA SINICA; 128 Academia Road Section 2, Nankang Taipei 115 (TW).
SHIH, Ming-Che [US/US]; (US)
Inventors: HSIEH, Patrick, C.H.; (TW).
CHEN, Chen-Yun; (TW).
CHENG, Yu-Che; (TW)
Agent: CHEN, Yahua; (US)
Priority Data:
62/402,255 30.09.2016 US
Title (EN) MICRORNA LET-7 AND TRANSFORMING GROWTH FACTOR BETA RECEPTOR III AXIS AS TARGET FOR CARDIAC INJURIES
(FR) MICROARN LET-7 ET TRANSFORMATION DE L'AXE DU RÉCEPTEUR DU FACTEUR DE CROISSANCE TRANSFORMANT BÊTA III EN TANT QUE CIBLE POUR DES LÉSIONS CARDIAQUES
Abstract: front page image
(EN)Methods for ameliorating cardiac injuries such as myocardial infarction by either enhancing the activity of a let-7 microRNA or inhibiting the activity of transformation growth factor beta receptor III (TGFBR3). Also provided herein are assay methods for detecting the level of TGFBR3, the level of a let-7 microRNA, or both in a biological sample.
(FR)L'invention concerne des procédés destinés à atténuer des lésions cardiaques telles que l'infarctus du myocarde en augmentant l'activité d'un microARN let-7 ou en inhibant l'activité du récepteur du facteur de croissance transformant bêta III (TGFBR3). L'invention concerne également des procédés de dosage permettant de détecter le niveau de TGFBR3, le niveau d'un microARN let-7, ou les deux dans un échantillon biologique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)