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1. (WO2018064377) TRANSDERMAL DRUG DELIVERY DEVICE FOR DELIVERING OPIOIDS
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Pub. No.: WO/2018/064377 International Application No.: PCT/US2017/054093
Publication Date: 05.04.2018 International Filing Date: 28.09.2017
IPC:
A61K 9/00 (2006.01) ,A61K 31/485 (2006.01) ,A61P 25/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
485
Morphinan derivatives, e.g. morphine, codeine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
04
Centrally acting analgesics, e.g. opioids
Applicants:
CHRONO THERAPEUTICS INC. [US/US]; 3953 Point Eden Way Hayward, CA 94545, US
Inventors:
STILES, Pete, A.; US
HOOTEN, W., Michael; US
SULLIVAN, Mark, Daniel; US
RUANE, Patrick, H.; US
MATLY, David, J.; US
KAUR, Navdeep; US
ARORA, Anubhav; US
PAMNANI, Ravinder D.; US
Agent:
BUCKINGHAM, David, K.; US
GLENN, W., Benjamin; US
ZLOGAR, Thomas, M.; US
BUCKINGHAM, David, K.; US
LIMBACH, Douglas, C.; US
Priority Data:
62/401,04328.09.2016US
Title (EN) TRANSDERMAL DRUG DELIVERY DEVICE FOR DELIVERING OPIOIDS
(FR) DISPOSITIF D’ADMINISTRATION TRANSDERMIQUE DE MÉDICAMENT POUR ADMINISTRER DES OPIOÏDES
Abstract:
(EN) Systems and methods are provided herein for transdermal delivery of an opioid. The opioids can be delivered in a decreasing dose (dose-tapering) manner to minimize withdrawal symptoms and abuse. The systems are also designed to limit a person besides the patient from receiving the drug with the transdermal delivery device. The systems can also include abuse- deterrence features that limit the ability of a patient or unauthorized user from tampering with the device to receive the active ingredient. Novel transdermal drug delivery formulations are also provided that include an opioid agonist or partial agonist and opioid antagonist which prevent the abuse of formulation.
(FR) La présente invention concerne des systèmes et des procédés pour l’administration transdermique d’un opioïde. Les opioïdes peuvent être administrés à une dose décroissante (diminution de dose) pour réduire au minimum les symptômes de sevrage et l’abus. Les systèmes sont également conçus pour éviter qu’une personne à côté du patient reçoive le médicament avec le dispositif d’administration transdermique. Les systèmes peuvent comprendre en outre des éléments anti-abus qui limitent la capacité d’un patient ou d’un utilisateur non autorisé à efectuer une manipulation frauduleuse du dispositif pour recevoir la substance active. L’invention concerne en outre de nouvelles formulations d’administration transdermique de médicament qui comprennent un agoniste opioïde ou un agoniste partiel et un antagoniste opioïde qui empêchent l’abus de formulation.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)